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Therapeutic Benefit of Smoked Cannabis in Randomized Placebo-Controlled Studies
- Source :
- Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 38:80-85
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- The medicinal use of marijuana has been legalized in 28 states, with a wide range of specificity for approved medical conditions. Even with the emergence of non–combustion-based delivery systems, in 2014, 90% of marijuana users used smoked marijuana. The purpose of this review is to summarize the data available on use of smoked marijuana for medical purposes. A literature search was performed to retrieve randomized controlled trials exploring the efficacy of smoked cannabis for treatment of a medical condition. Studies with the primary endpoint listed as the effect of smoked cannabis on a disease-specific characteristic were included. Open-label studies and studies using other administration methods were excluded. Seven studies met these criteria and were included in this review. Cannabis did not outperform placebo on experimentally evoked pain or times walk test. There is clear evidence that smoked cannabis reduces intraocular pressure, but the effect is too brief (< 4 hours) to be of therapeutic benefit for this chronic disorder. There was also consistent evidence that smoked marijuana, even at lower concentrations of tetrahydrocannabinol, increased total daily calorie intake and number of eating occasions. Neither of the studies with quality of life as secondary outcome measures revealed statistically significantly improved outcomes with cannabis use.
- Subjects :
- medicine.medical_specialty
Pain
Marijuana Smoking
Medical Marijuana
Anorexia
Placebo
Article
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Quality of life
law
Internal medicine
Clinical endpoint
Humans
Medicine
Pharmacology (medical)
Dronabinol
030212 general & internal medicine
Tetrahydrocannabinol
Intraocular Pressure
Randomized Controlled Trials as Topic
biology
business.industry
biology.organism_classification
Treatment Outcome
Quality of Life
Cannabis
medicine.symptom
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 02770008
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
- Accession number :
- edsair.doi.dedup.....ef61ae7e52406dbc0a42f31f0e3560ee