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Behavioral and biochemical evidence for serotonergic actions of tetrahydro-beta-carbolines
- Source :
- Life sciences. 31(22)
- Publication Year :
- 1982
-
Abstract
- In two groups of rats trained to discriminate LSD (0.1 mg/kg or 0.24 mg/kg) from saline, tetrahydro-β-carboline (THBC; 1–12 mg/kg as free base) and its derivative 6-methoxy-THBC (1–12 mg/kg as free base) substituted partially for LSD. The substitution of THBC for 0.1 mg/kg of LSD was analyzed further with antagonism tests in 16 animals and was attenuated by the serotonin (5-HT) antagonist BC-105 (pizotifen; 3 mg/kg) but not by the dopamine (DA) antagonist haloperidol (0.1 mg/kg). It was abolished by pre-treatment with the 5-HT synthesis inhibitor p-chlorophenylalanine (100 mg/kg/day for 3 days). In addition, THBC was found to inhibit 3 H-LSD binding to homogenates of rat frontal cortex with an IC 50 value of 4 μM which is similar to that previously reported for other 5-HT agonists. These data indicate that THBCs exert potent 5-HT agonist actions. Since THBCs have recently been found in mammalian brain and other tissues, the present results are of interest in relation to a possible role of these substances in endogenous psychosis.
- Subjects :
- Agonist
Male
Serotonin
Indoles
medicine.drug_class
Pharmacology
Pizotifen
Serotonergic
General Biochemistry, Genetics and Molecular Biology
Discrimination Learning
Dopamine
medicine
Haloperidol
Animals
General Pharmacology, Toxicology and Pharmaceutics
Behavior, Animal
Chemistry
Antagonist
Rats, Inbred Strains
General Medicine
Rats
Lysergic Acid Diethylamide
Antagonism
medicine.drug
Carbolines
Subjects
Details
- ISSN :
- 00243205
- Volume :
- 31
- Issue :
- 22
- Database :
- OpenAIRE
- Journal :
- Life sciences
- Accession number :
- edsair.doi.dedup.....ef5c2855c75688642c4263c19a87c263