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Systemic sclerosis and the gastrointestinal tract
- Source :
- Gastroenterology Review, Vol 12, Iss 3, Pp 163-168 (2017), Przegla̜d Gastroenterologiczny
- Publication Year :
- 2017
- Publisher :
- Termedia Publishing House, 2017.
-
Abstract
- Systemic sclerosis (SSc) is an autoimmunological disease of unknown origin with complex pathogenesis and multiple organ involvement. It is characterised by vascular and immunological abnormalities leading to fibrosis of the skin and internal organs. It is a rather rare disease with a prevalence of around 20 per 100,000. The disease results in heterogeneous clinical findings and different courses. Systemic sclerosis usually begins with the onset of Raynaud’s phenomenon (RP), followed by skin sclerosis and internal organ involvement, although it may appear synchronously with RP. Gastrointestinal involvement is a serious and prevalent complication of SSc, and the oesophagus is the most frequently affected organ. Both limited and diffuse cutaneous SSc involve internal organs, with the involvement of the gastrointestinal tract as a leading cause of morbidity. At present, treatment is mainly symptomatic with no disease-modifying drugs.
- Subjects :
- Pathology
medicine.medical_specialty
gastrointestinal involvement
systemic sclerosis
autoantibodies
lcsh:Medicine
Disease
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Fibrosis
Medicine
030203 arthritis & rheumatology
Review Paper
Gastrointestinal tract
integumentary system
business.industry
lcsh:R
Gastroenterology
Autoantibody
medicine.disease
030211 gastroenterology & hepatology
Skin sclerosis
business
Complication
Rare disease
Subjects
Details
- Language :
- English
- ISSN :
- 18974317 and 18955770
- Volume :
- 12
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Gastroenterology Review
- Accession number :
- edsair.doi.dedup.....ef54a67f48c8514123044ee80be992a4