Back to Search
Start Over
From formulation of acrylamide-based hydrogels to their optimization for drug release using response surface methodology
- Source :
- Materials Science and Engineering: C. 92:20-25
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- This study conducted on the structure of modified acrylamide-based hydrogel by synthesizing the nano composites. The hydrogels employed in this study were provided through a combination of acrylamide monomers, sodium carboxymethyl cellulose (NaCMC) and magnesium oxide (MgO) nanoparticles by crosslinking polymerization. N,N,N′,N′-tetramethylethylenediamine and ammonium persulfate as the initiator was applied in the structure of the polymer. Findings of the study considered the nano composites consisting of MgO have the highest swelling ratio compared to pure Aam hydrogels. Thus, MgO is an appropriate nanoparticle to be used in the nano composites. Response surface methodology (RSM) based on a central composite design (CCD Design) was applied to optimize the preparation variables of a hydrogel consisted of MgO, NaCMC. With the swelling ratio for acrylamide-based hydrogel as the response, the effects of two variables, i.e. MgO and NaCMC were investigated. The effects of pH, temperature, MgO, and NaCMC on the drug release were investigated using the CCD design. The predicted appropriate drug release conditions for the hydrogel at the highest rate of temperature (37.50 °C) and pH: 4.10, is at its highest value, while the lower drug release is at temperature 38 °C and pH 3.50. With the desired value of MgO (0.01 g) and amount of NaCMC (0.1 g).
- Subjects :
- Materials science
Central composite design
Polymers
Acyclovir
Bioengineering
macromolecular substances
02 engineering and technology
010402 general chemistry
01 natural sciences
Biomaterials
chemistry.chemical_compound
medicine
Response surface methodology
chemistry.chemical_classification
Acrylamide
Drug Carriers
Temperature
technology, industry, and agriculture
Hydrogels
Polymer
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
0104 chemical sciences
Carboxymethyl cellulose
Drug Liberation
Pharmaceutical Preparations
Polymerization
chemistry
Chemical engineering
Mechanics of Materials
Carboxymethylcellulose Sodium
Self-healing hydrogels
Nanoparticles
Ammonium persulfate
Magnesium Oxide
0210 nano-technology
medicine.drug
Subjects
Details
- ISSN :
- 09284931
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Materials Science and Engineering: C
- Accession number :
- edsair.doi.dedup.....ef4bd1c9614d1594246cff5271a938d6