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Prevalence and Associated Factors of Frailty and Mortality in Patients with End-Stage Renal Disease Undergoing Hemodialysis: A Systematic Review and Meta-Analysis
- Source :
- International Journal of Environmental Research and Public Health, International Journal of Environmental Research and Public Health, Vol 18, Iss 3471, p 3471 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Hemodialysis is the most common type of treatment for end-stage renal disease (ESRD). Frailty is associated with poor outcomes such as higher mortality. ESRD patients have a higher prevalence of frailty. This systematic review and meta-analysis aimed to identify the prevalence and associated factors of frailty and examine whether it is a predictor of mortality among ESRD patients undergoing hemodialysis. Five electronic databases including PubMed, Embase, CINAHL, Web of Science, and Cochrane Library were searched for relevant studies up to 30 November 2020. A total of 752 articles were found, and seven studies with 2604 participants in total were included in the final analysis. The pooled prevalence of frailty in patients with ESRD undergoing hemodialysis was 46% (95% Confidence interval (CI) 34.2−58.3%). Advanced age, female sex, and the presence of diabetes mellitus increased the risk of frailty in ESRD patients undergoing hemodialysis. Our main finding showed that patients with frailty had a greater risk of all-cause mortality compared with those without (hazard ratio (HR): 2.02, 95% CI: 1.65−2.48). To improve ESRD patient outcomes, healthcare professionals need to assess the frailty of older ESRD patients, particularly by considering gender and comorbidities. Comprehensive frailty screening tools for ESRD patients on hemodialysis need to be developed.
- Subjects :
- medicine.medical_specialty
Health, Toxicology and Mutagenesis
medicine.medical_treatment
kidney disease
030232 urology & nephrology
lcsh:Medicine
Review
Comorbidity
Cochrane Library
urologic and male genital diseases
End stage renal disease
03 medical and health sciences
0302 clinical medicine
systematic review
Renal Dialysis
Internal medicine
medicine
Prevalence
Humans
030212 general & internal medicine
Risk factor
hemodialysis
Frailty
business.industry
lcsh:R
Hazard ratio
Public Health, Environmental and Occupational Health
medicine.disease
mortality
Confidence interval
risk factor
Meta-analysis
Kidney Failure, Chronic
Female
Hemodialysis
business
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 16604601 and 16617827
- Volume :
- 18
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....ef458c48b03440fe87cf0ba95d6c00b2