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The COVIDome Explorer Researcher Portal
- Source :
- medRxiv, article-version (status) pre, article-version (number) 1, Cell Reports
- Publication Year :
- 2021
- Publisher :
- Cold Spring Harbor Laboratory, 2021.
-
Abstract
- COVID-19 pathology involves dysregulation of diverse molecular, cellular, and physiological processes. To expedite integrated and collaborative COVID-19 research, we completed multi-omics analysis of hospitalized COVID-19 patients, including matched analysis of the whole-blood transcriptome, plasma proteomics with two complementary platforms, cytokine profiling, plasma and red blood cell metabolomics, deep immune cell phenotyping by mass cytometry, and clinical data annotation. We refer to this multidimensional dataset as the COVIDome. We then created the COVIDome Explorer, an online researcher portal where the data can be analyzed and visualized in real time. We illustrate herein the use of the COVIDome dataset through a multi-omics analysis of biosignatures associated with C-reactive protein (CRP), an established marker of poor prognosis in COVID-19, revealing associations between CRP levels and damage-associated molecular patterns, depletion of protective serpins, and mitochondrial metabolism dysregulation. We expect that the COVIDome Explorer will rapidly accelerate data sharing, hypothesis testing, and discoveries worldwide.<br />Graphical Abstract<br />Sullivan et al. describe the development of a multidimensional dataset for the study of COVID-19 known as the COVIDome, which includes diverse clinical, transcriptome, proteome, metabolome, and immune cell datasets. A researcher portal known as the COVIDome Explorer was created to enable global data access and analysis.
- Subjects :
- Resource
Adult
Male
Proteomics
Poor prognosis
Proteome
Coronavirus disease 2019 (COVID-19)
Datasets as Topic
Computational biology
Biology
Article
General Biochemistry, Genetics and Molecular Biology
Access to Information
Cytokine profiling
Transcriptome
Young Adult
Metabolomics
data portal
Databases, Genetic
Metabolome
Data Mining
Humans
Mass cytometry
SARS
Gene Expression Profiling
serpins
COVID-19
multi-omics
Middle Aged
Data science
infection
Data sharing
Gene expression profiling
immune system
Data portal
inflammation
Case-Control Studies
Multi omics
Female
Plasma proteomics
CRP
Psychology
metabolism
Data Annotation
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- medRxiv, article-version (status) pre, article-version (number) 1, Cell Reports
- Accession number :
- edsair.doi.dedup.....ef3b66441d35064d46be4398f25cca9b