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A four-protein metabolon assembled by a small peptide protein creates the pentacyclic carbonate ring of aldgamycins
- Source :
- Acta Pharmaceutica Sinica. B, Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 588-597 (2021)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Organic carbonates (OCs) are a class of compounds featured by a carbonyl flanked by two alkoxy/aryloxy groups. They exist in either linear or cyclic forms, of which the majority encountered in nature adopt a pentacyclic structure. However, the enzymatic basis for pentacyclic carbonate ring formation remains elusive. Here, we reported that a four-protein metabolon (AlmUIIāUV) assembled by a small peptide protein (AlmUV) appends a reactive N-hydroxylcarbamoyl moiety to the decarboxylated aldgamycins followed by a non-enzymatic condensation to give the pentacyclic carbonate ring. Our results have documented an unprecedent mechanism for carbonate formation.<br />Graphical abstract The pentacyclic carbonate ring of aldgamycins is formed by a four-protein metabolon assembled by a small peptide protein, which begins with the attachment of a reactive N-hydroxylcarbamoyl moiety followed by a non-enzymatic condensation.Image 1
- Subjects :
- 0303 health sciences
Chemistry
Stereochemistry
Organic carbonate
lcsh:RM1-950
Protein complex
Ring (chemistry)
Biosynthesis
Aldgamycins
03 medical and health sciences
chemistry.chemical_compound
lcsh:Therapeutics. Pharmacology
0302 clinical medicine
030220 oncology & carcinogenesis
Small peptide
Alkoxy group
Moiety
Carbonate
Original Article
Metabolon
General Pharmacology, Toxicology and Pharmaceutics
N-hydroxylcarbamoyl
030304 developmental biology
Subjects
Details
- Language :
- English
- ISSN :
- 22113843 and 22113835
- Volume :
- 11
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Acta Pharmaceutica Sinica. B
- Accession number :
- edsair.doi.dedup.....ef3b1f2a3281c5a8acce0f5a1cc55d76