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Effect of micropore/microsphere topography and a silicon-incorporating modified titanium plate surface on the adhesion and osteogenic differentiation of BMSCs
- Source :
- Artificial cells, nanomedicine, and biotechnology. 48(1)
- Publication Year :
- 2019
-
Abstract
- Good biological properties for titanium implants will shorten the treatment cycle and improve patient comfort, which are also the main goals of dentistry and orthopaedics. At present, the biological properties of titanium implants are mainly enhanced in two aspects: their surface chemistry and surface morphology. In this study, a surface modification strategy combining bioactive trace elements with surface micromorphology modification was used to enhance the biological properties of pure titanium. A new coating incorporating silicon micropore/microsphere topography was prepared on a titanium plate by micro-arc oxidation (MAO) technology. The properties of the coating and its effects on the adhesion and osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs) were further analyzed. The experimental results show that a coating doped with amorphous silicon with micropore/microsphere topography was incorporated onto the titanium surface and the surface roughness in the treated groups was obviously higher than that in the Ti group. In vitro, the presence of a silicon-incorporating coating with a micropore/microsphere topography on the titanium surface significantly enhanced the initial adhesion, proliferation and osteogenic differentiation of BMSCs. These results indicate that the silicon-incorporating coating with micropore/microsphere topography has potential applications in dentistry and orthopaedics.
- Subjects :
- Amorphous silicon
Silicon
Materials science
Surface Properties
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)
chemistry.chemical_element
02 engineering and technology
engineering.material
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Coating
Coated Materials, Biocompatible
Osteogenesis
Surface roughness
Cell Adhesion
Animals
Titanium
technology, industry, and agriculture
Cell Differentiation
Mesenchymal Stem Cells
General Medicine
Microporous material
Adhesion
equipment and supplies
021001 nanoscience & nanotechnology
Microspheres
Rats
chemistry
Chemical engineering
030220 oncology & carcinogenesis
engineering
Surface modification
0210 nano-technology
Biotechnology
Subjects
Details
- ISSN :
- 2169141X
- Volume :
- 48
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Artificial cells, nanomedicine, and biotechnology
- Accession number :
- edsair.doi.dedup.....ef38a76870a7b641830b06f79223dde1