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Adjuvant systemic chemotherapy with or without bevacizumab in patients with resected liver metastases from colorectal cancer
- Source :
- Oncology. 84(1)
- Publication Year :
- 2012
-
Abstract
- Background: We aimed to investigate the impact of adjuvant systemic therapy with modern chemotherapy combinations on survival outcomes in patients with resected liver-confined metastases from colorectal carcinomas, and whether addition of bevacizumab (BEV) provides further benefit. Methods: A total of 229 consecutive patients who underwent resection for liver-confined colorectal liver metastases were retrospectively analyzed. Results: Of 229 patients, 204 who received chemotherapy with fluoropyrimidine-based (n = 27), irinotecan-based (n = 84) and oxaliplatin-based (n = 93) combinations were analyzed. Among these, 87 patients received BEV while 117 did not (NoBEV). With a median follow-up of 27 months after metastasectomy, the median recurrence-free survival (RFS) and overall survival (OS) were 17 and 53 months, respectively. OS rates at 3 and 5 years were 71% and 40%, respectively. No significant differences were found in the median RFS (p = 0.744) and OS (p = 0.440) among different chemotherapy regimens. The median RFS (p = 0.375) and OS (p = 0.251) were similar in BEV and NoBEV arms. In multivariate analysis, having 4 liver metastases was the only negative independent factor on both RFS and OS, while positive surgical margin was another negative independent factor for RFS. Conclusion: Chemotherapy type and addition of BEV have no impact on both RFS and OS in the adjuvant setting following complete resection of colorectal liver metastases.
- Subjects :
- Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Bevacizumab
Colorectal cancer
Adjuvant chemotherapy
medicine.medical_treatment
Angiogenesis Inhibitors
Antibodies, Monoclonal, Humanized
Systemic therapy
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
In patient
Neoplasm Metastasis
Aged
Retrospective Studies
Aged, 80 and over
business.industry
Systemic chemotherapy
Liver Neoplasms
General Medicine
Middle Aged
medicine.disease
Prognosis
Combined Modality Therapy
Chemotherapy combinations
Survival Rate
Chemotherapy, Adjuvant
Female
Neoplasm Recurrence, Local
business
Colorectal Neoplasms
Adjuvant
medicine.drug
Follow-Up Studies
Subjects
Details
- ISSN :
- 14230232
- Volume :
- 84
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Oncology
- Accession number :
- edsair.doi.dedup.....ef34f4fc7710f5a1de1b29a92195fd61