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Molecular Signatures of Dengue Virus-Specific IL-10/IFN-γ Co-producing CD4 T Cells and Their Association with Dengue Disease
- Source :
- Cell reports, Cell Reports, Vol 29, Iss 13, Pp 4482-4495.e4 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- SUMMARY Dengue virus (DENV) can cause diseases ranging from dengue fever (DF) to more severe dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Whether antiviral T cells contribute to the protection against or pathogenesis of severe disease is not well defined. Here, we identified antigen-specific IL-10+IFN-γ+ double-positive (DP) CD4 T cells during acute DENV infection. While the transcriptomic signatures of DP cells partially overlapped with those of cytotoxic and type 1 regulatory CD4 T cells, the majority of them were non-cytotoxic/Tr1 and included IL21, IL22, CD109, and CCR1. Although we observed a higher frequency of DP cells in DHF, the transcriptomic profile of DP cells was similar in DF and DHF, suggesting that DHF is not associated with the altered phenotypic or functional attributes of DP cells. Overall, this study revealed a DENV-specific DP cell subset in patients with acute dengue disease and argues against altered DP cells as a determinant of DHF.<br />In Brief Tian et al. identify and characterize antigen-specific IL-10+IFN-γ+ double-positive (DP) CD4 T cells in acute dengue patients. DP cells display similar transcriptomic profiles in mild DF and severe DHF, despite their increased frequency in DHF, suggesting that DHF is not associated with the altered phenotype or functionality of DP cells.<br />Graphical Abstract
- Subjects :
- Adult
Male
0301 basic medicine
CCR1
Adolescent
Receptors, CCR1
Biology
Dengue virus
GPI-Linked Proteins
medicine.disease_cause
Severity of Illness Index
T-Lymphocytes, Regulatory
Article
General Biochemistry, Genetics and Molecular Biology
Dengue fever
Transcriptome
Pathogenesis
Interleukin 22
Interferon-gamma
03 medical and health sciences
0302 clinical medicine
Antigens, CD
medicine
Humans
Cytotoxic T cell
Severe Dengue
lcsh:QH301-705.5
Interleukins
virus diseases
Dengue Virus
Middle Aged
medicine.disease
Virology
Interleukin-10
Neoplasm Proteins
3. Good health
Interleukin 10
030104 developmental biology
lcsh:Biology (General)
Gene Expression Regulation
Case-Control Studies
Female
030217 neurology & neurosurgery
Signal Transduction
T-Lymphocytes, Cytotoxic
Subjects
Details
- ISSN :
- 22111247
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Cell Reports
- Accession number :
- edsair.doi.dedup.....ef2fe919a13c7331a97670011419cf8f