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Transmission Disequilibrium Analysis of a Triplet Repeat within thehKCa3Gene Using Family Trios with Schizophrenia
- Source :
- Biochemical and Biophysical Research Communications. 251:662-665
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- hKCa3 is a neuronal small conductance calcium-activated potassium channel which contains a polyglutamine tract, encoded by a polymorphic CAG repeat in the gene. Since an association between longer alleles of the CAG repeat and schizophrenia has been reported, we performed haplotype-based haplotype relative risk (HHRR) and transmission disequilibrium (TDT) in 97 family trios with schizophrenia from SW China. We found no evidence for an excess of longer CAG repeats in the patients, and the ETDT test was not significant for either allele-wise (P = 0.31) or genotype-wise analysis (P = 0.18). However, there was a deficit of transmission of the (CAG) 20 repeat allele to affected offspring when this allele was considered individually by TDT (P = 0.012; not corrected for multiple testing). These data do not support a role for larger alleles at the hKCa3 locus in psychosis in Chinese subjects.
- Subjects :
- Adult
Male
Risk
China
Psychosis
Potassium Channels
Adolescent
Genotype
Small-Conductance Calcium-Activated Potassium Channels
Molecular Sequence Data
Disequilibrium
Biophysics
Locus (genetics)
Biology
Biochemistry
Linkage Disequilibrium
Potassium Channels, Calcium-Activated
Trinucleotide Repeats
mental disorders
medicine
Humans
Allele
Molecular Biology
Gene
Alleles
Aged
Genetics
Haplotype
Chromosome Mapping
Cell Biology
Middle Aged
Polyglutamine tract
medicine.disease
Haplotypes
Chromosomes, Human, Pair 1
Multiple comparisons problem
Schizophrenia
Female
medicine.symptom
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 251
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....ef26baf0e9f6cb6d68001e0b693a5ec0