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Immunosuppressant HR-325 Attenuates Progression of Malignant Arteritis in the Kidney of Dahl Salt-Sensitive Rats
- Source :
- Hypertension Research. 20:91-97
- Publication Year :
- 1997
- Publisher :
- Japanese Society of Hypertension, 1997.
-
Abstract
- We investigated the effects of the immunosuppressant HR-325 on arterial lesions in Dahl rats with salt-induced hypertension. Forty-eight 6-wk-old Dahl salt-sensitive (DS) rats were divided into 1) a low-salt (0.3% NaCl) group, 2) a high-salt (4% NaCl) group, 3) a high-salt and low-dose (1 mg/kg) HR-325 group, and 4) a high-salt and high-dose (30 mg/kg) HR-325 group. The rats were treated for 8 wk. Various variables of renal function and morphological alterations in the kidney were assessed. Blood pressure was measured by the tail-cuff method. HR-325 significantly decreased systolic blood pressure in a dose-dependent manner throughout the study. HR-325 tended to decrease plasma creatinine level and increase creatinine clearance rate. Morphological studies revealed that HR-325 treatment strikingly resolved infiltration of immune-related cells in perivascular and intraluminal lesions, thereby decreasing the total arterial injury score by 32%. High-dose HR-325 also attenuated glomerulosclerosis and tubular injury by 35% and 34%, respectively, as compared with untreated high-salt Dahl S rats. Reduced levels of immune-related cells resulted in a decrease in urinary nitrite excretion. These data indicate that long-term treatment with the immunosuppressant HR-325 decreases systolic blood pressure in Dahl salt-sensitive rats, and that this decrease is associated particularly with resolution of infiltration of immune-related cells in arterial lesions. Hyperimmune state is responsible in part for the susceptibility of Dahl S rats to hypertensive organ damage.
- Subjects :
- medicine.medical_specialty
Physiology
Urinary system
Renal function
Blood Pressure
Nitric Oxide
Nitric oxide
Excretion
chemistry.chemical_compound
Renal Artery
Internal medicine
Internal Medicine
medicine
Animals
Arteritis
Kidney
Aniline Compounds
business.industry
Hemodynamics
Glomerulosclerosis
Creatine
medicine.disease
Rats
medicine.anatomical_structure
Endocrinology
Blood pressure
chemistry
Multivariate Analysis
Cardiology and Cardiovascular Medicine
business
Immunosuppressive Agents
Subjects
Details
- ISSN :
- 13484214 and 09169636
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Hypertension Research
- Accession number :
- edsair.doi.dedup.....ef215675e1a5612b857afe6b775c85d8