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Saliva as a diagnostic tool for dental caries, periodontal disease and cancer: is there a need for more biomarkers?
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2020
-
Abstract
- Introduction: A biomarker is a biological indicator of normal or pathogenic processes. Identification of biomarkers is useful for the prevention, diagnosis and prognosis of diseases as well as for monitoring the progression of pathological disorders. Several types of molecules present in biological fluids can act as biomarkers such as DNA, coding and non-coding RNA, lipids, metabolites, proteins and even microbes. In this context, saliva emerges as a useful diagnostic tool for the detection of biomarkers involved with oral and systemic diseases, since it reflects the pathophysiological conditions of the organism and allows early, rapid, practical and noninvasive detection of biomarkers.Areas covered: This review discusses the properties of saliva as a diagnostic tool and addresses the main identified biomarkers related to dental caries, periodontal disease, head and neck cancer and other types of cancer of considerable incidence among the world population.Expert commentary: Despite extensive efforts which have been directed toward the identification of one or a combination of biomarkers with good predictive values for the early detection of dental caries, periodontal disease and cancer, these biomarkers still need validation before chairside point-of-care devices can be widely used in the clinic.
- Subjects :
- 0301 basic medicine
Saliva
Point-of-Care Systems
Early detection
Context (language use)
Dental Caries
Bioinformatics
Pathology and Forensic Medicine
BIOMARCADORES
03 medical and health sciences
0302 clinical medicine
PATHOLOGICAL DISORDERS
Periodontal disease
Neoplasms
Genetics
medicine
Humans
Molecular Biology
Periodontal Diseases
business.industry
Head and neck cancer
Cancer
medicine.disease
Prognosis
030104 developmental biology
Molecular Diagnostic Techniques
030220 oncology & carcinogenesis
Molecular Medicine
Biomarker (medicine)
Disease Susceptibility
business
Biomarkers
Subjects
Details
- ISSN :
- 17448352
- Volume :
- 20
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Expert review of molecular diagnostics
- Accession number :
- edsair.doi.dedup.....ef1b2aa856117d55a0f7c02b1010bec3