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Impaired acute collateral recruitment as a possible mechanism for increased cardiac adverse events in patients with diabetes mellitus
- Source :
- European heart journal. 24(12)
- Publication Year :
- 2003
-
Abstract
- Background The mortality of coronary artery disease is increased in diabetic patients. An impaired collateral function is considered a possible explanation. This study should assess the influence of diabetes on collaterals by direct invasive assessment of collateral function. Methods In 90 consecutive patients with a chronic coronary occlusion (TCO) of >2 weeks duration a recanalization was done. Thirty patients with diabetes (33%) were compared with 60 (67%) without diabetes. Blood flow velocity and pressure were measured distal to the occlusion by intracoronary Doppler and pressure wires before PTCA, and again after PTCA during a final balloon reocclusion to assess acute recruitment of collaterals. Resistance indexes for collaterals (RColl) and peripheral microcirculation (RP) were calculated. Results The RColl(diabetics: 8.1±6.8 vs nondiabetics: 8.7±6.7mmHgcm−1s−1; p=0.68) and RP(5.6±4.2 vs 6.6±3.8mmHgcm−1s−1; p=0.30) were similar in diabetic and nondiabetic patients before recanalization. During balloon reocclusion both RColland RPincreased. This increase was significantly more pronounced in diabetic than in nondiabetic patients in TCOs
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Collateral Circulation
Blood Pressure
Coronary artery disease
Internal medicine
Angioplasty
Diabetes mellitus
Coronary Circulation
Occlusion
Medicine
Humans
Angioplasty, Balloon, Coronary
Adverse effect
business.industry
Coronary Stenosis
Middle Aged
medicine.disease
Collateral circulation
Coronary occlusion
Circulatory system
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Blood Flow Velocity
Diabetic Angiopathies
Subjects
Details
- ISSN :
- 0195668X
- Volume :
- 24
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- European heart journal
- Accession number :
- edsair.doi.dedup.....ef10f37353b97f0caaba8cd407d214f6