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Optimal donor for severe aplastic anemia patient requiring allogeneic hematopoietic stem cell transplantation: A large-sample study from China
- Source :
- Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018), Scientific Reports
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- HLA-haploidentical hematopoietic stem cell transplantation (HSCT) may be an option for severe aplastic anemia (SAA) patients. However, to date, no large-sample studies have been performed to determine which types of SAA patients are suitable for HLA-haploidentical HSCT. We retrospectively studied 189 consecutive patients with SAA who underwent HLA-identical or HLA-haploidentical HSCT at seven transplant centers in China. Propensity score matching (PSM) was applied in this study to reduce the influence of potential confounders. The 5-year overall survival (OS) rate was 72.0% in the HLA-haploidentical group and 76.5% in the HLA-identical group. The median time to achieve engraftment and the incidence of acute GVHD/chronic GVHD were not significantly different between the two groups. In the subgroup analysis, the outcome of patients older than 40 years in the HLA-haploidentical group was significantly poorer than that of patients younger than 40 years in the same group and that of patients older than 40 years in the HLA-identical group. Based on the above results, we suggest that HLA-haploidentical relative HSCT should be considered as a valid alternative option for patients younger than 40 years with SAA for whom no matched sibling donor is available.
- Subjects :
- Male
medicine.medical_treatment
Gene Expression
Graft vs Host Disease
lcsh:Medicine
Histocompatibility Testing
Hematopoietic stem cell transplantation
Severity of Illness Index
0302 clinical medicine
HLA Antigens
hemic and lymphatic diseases
Medicine
Child
lcsh:Science
Multidisciplinary
Incidence (epidemiology)
Hematopoietic Stem Cell Transplantation
Anemia, Aplastic
Middle Aged
Tissue Donors
surgical procedures, operative
030220 oncology & carcinogenesis
Child, Preschool
Acute Disease
Female
Adult
medicine.medical_specialty
China
Adolescent
Subgroup analysis
Article
03 medical and health sciences
Internal medicine
Severity of illness
Humans
Propensity Score
Survival analysis
Retrospective Studies
business.industry
lcsh:R
Retrospective cohort study
Survival Analysis
Sample Size
Propensity score matching
Chronic Disease
Transplantation, Haploidentical
lcsh:Q
business
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....ef045c62959fc8be835b8b554286ebc9