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Association of Cyr61-cysteine-rich protein 61 and short-term mortality in patients with acute heart failure and coronary heart disease
- Source :
- Biomarkers in medicine. 13(18)
- Publication Year :
- 2019
-
Abstract
- Aim: The protein CCN1/CYR61 exerts critical functions in myocardial ischemic injury. We sought to investigate the prognostic value of CCN1 in patients with acute heart failure (AHF) and coronary heart disease (CAD). Methodology: We prospectively enrolled 113 patients with AHF and CAD. Patients were followed for all-cause mortality during a 30-day follow-up. Logistic models were used to estimate the association of CCN1 concentrations with 30-day mortality. Results: In multivariate logistic regression model, CCN1 was a significant predictor of 30-day mortality independent of current markers. Enhanced Feedback for Effective Cardiac Treatment risk score was recommended as one of the selected multivariable risk scores to predict outcome in AHF. CCN1 improved risk stratification for all-cause mortality when added to the Enhanced Feedback for Effective Cardiac Treatment risk scores at 30 days. Conclusion: We found CCN1 is independently associated with 30-day mortality in patients with AHF and CAD.
- Subjects :
- Male
medicine.medical_specialty
Clinical Biochemistry
Short term mortality
Coronary Disease
030204 cardiovascular system & hematology
Cysteine rich protein
03 medical and health sciences
0302 clinical medicine
Internal medicine
Drug Discovery
medicine
Humans
In patient
Prospective Studies
Aged
Aged, 80 and over
Heart Failure
Framingham Risk Score
business.industry
Biochemistry (medical)
Middle Aged
medicine.disease
Coronary heart disease
Multivariate logistic regression model
030220 oncology & carcinogenesis
CYR61
Heart failure
Acute Disease
Cardiology
Female
business
Biomarkers
Cysteine-Rich Protein 61
Follow-Up Studies
Subjects
Details
- ISSN :
- 17520371
- Volume :
- 13
- Issue :
- 18
- Database :
- OpenAIRE
- Journal :
- Biomarkers in medicine
- Accession number :
- edsair.doi.dedup.....eefc6b7b93dc51e2047eff1cac3ad6ff