Back to Search Start Over

Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma

Authors :
Shu Wang
Jing He Lang
Keng Shen
Yi-Min Qu
Yu-Ting Ji
Yu Zhao
Source :
Journal of Ovarian Research, Vol 10, Iss 1, Pp 1-9 (2017), Journal of Ovarian Research
Publication Year :
2017
Publisher :
BMC, 2017.

Abstract

Background This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. Methods The present study reviewed the medical records of patients who received initial treatment and a postoperative pathological diagnosis of ovarian endometrioid carcinoma at our center. In all, 78 patients had stage I ovarian endometrioid carcinoma. Results In this series, the 5-year overall survival rate and 5-year disease-free survival (DFS) rates of patients with stage I ovarian endometrioid carcinoma was 98.7% and 87.2%, respectively. Univariate analysis showed the factors that influence the DFS rates include menopausal status, FIGO stage, histological grade, lymphadenectomy, cytology of ascites. Multivariate analysis showed that grade 3 and lymphadenectomy were the independent prognostic factors of DFS for Stage I ovarian endometrioid carcinoma (P = 0.0259, 0.0276 respectively). However, the coexisting endometriosis, concomitant endometrial disorders, dissection of para-aortic lymph node and more courses of thermotherapy had no influence on DFS. Besides, it was found that 19.3% of patients in this series had synchronous early stage and well-to-moderate differentiated endometrial carcinoma. Conclusions Grade 3 and lymphadenectomy were indicated as the independent factors of DFS for stage I patients with ovarian endometrioid carcinoma. The endometrial changes should be considered seriously when fertility-sparing surgery was planned.

Details

Language :
English
ISSN :
17572215
Volume :
10
Issue :
1
Database :
OpenAIRE
Journal :
Journal of Ovarian Research
Accession number :
edsair.doi.dedup.....eeef847886164d7e111eb69d3bd5e10e