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Genomic Variations in the Structural Proteins of SARS-CoV-2 and Their Deleterious Impact on Pathogenesis: A Comparative Genomics Approach
- Source :
- Frontiers in Cellular and Infection Microbiology, Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- A continual rise in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection causing coronavirus disease (COVID-19) has become a global threat. The main problem comes when SARS-CoV-2 gets mutated with the rising infection and becomes more lethal for humankind than ever. Mutations in the structural proteins of SARS-CoV-2, i.e., the spike surface glycoprotein (S), envelope (E), membrane (M) and nucleocapsid (N), and replication machinery enzymes, i.e., main protease (Mpro) and RNA-dependent RNA polymerase (RdRp) creating more complexities towards pathogenesis and the available COVID-19 therapeutic strategies. This study analyzes how a minimal variation in these enzymes, especially in S protein at the genomic/proteomic level, affects pathogenesis. The structural variations are discussed in light of the failure of small molecule development in COVID-19 therapeutic strategies. We have performed in-depth sequence- and structure-based analyses of these proteins to get deeper insights into the mechanism of pathogenesis, structure-function relationships, and development of modern therapeutic approaches. Structural and functional consequences of the selected mutations on these proteins and their association with SARS-CoV-2 virulency and human health are discussed in detail in the light of our comparative genomics analysis.
- Subjects :
- Microbiology (medical)
Proteomics
viruses
Immunology
Genomics
Computational biology
severe acute respiratory syndrome coronavirus-2
Biology
medicine.disease_cause
Microbiology
Pathogenesis
chemistry.chemical_compound
coronavirus disease 2019
Cellular and Infection Microbiology
RNA polymerase
medicine
Humans
Coronavirus
Original Research
Comparative genomics
chemistry.chemical_classification
Mechanism (biology)
SARS-CoV-2
SARS-CoV-2 pathogenesis
COVID-19
QR1-502
Infectious Diseases
chemistry
SARS-CoV-2 mutations
Spike Glycoprotein, Coronavirus
Glycoprotein
single amino acid substitutions
Subjects
Details
- Language :
- English
- ISSN :
- 22352988
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Cellular and Infection Microbiology
- Accession number :
- edsair.doi.dedup.....eeecbab4221ddc59af0a3734be109bb3