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Self‐Adhesive Silicone Microstructures for the Treatment of Tympanic Membrane Perforations
- Source :
- Advanced NanoBiomed Research, Vol 1, Iss 10, Pp n/a-n/a (2021)
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Inspired by the gecko foot, polymeric microstructures have demonstrated reliable dry adhesion to both stiff objects and sensitive surfaces such as skin. Microstructured silicone patches are proposed, herein, for the treatment of tympanic membrane perforations with the aim of serving as an alternative for current surgical procedures that require anesthesia and ear canal packing. Sylgard 184 PDMS micropillars of 20 μm in diameter and 60 μm in length are topped by a Soft Skin Adhesive (SSA) MG7‐1010 terminal layer, of about 25 μm thickness. The adhesion is evaluated by specially designed tack tests against explanted murine eardrums and, for comparison, against a rigid substrate. Functional effects are evaluated using auditory brainstem responses (ABRs) and distortion product otoacoustic emissions (DPOAE). The adhesion strength of the microstructure and unstructured controls to explanted murine tympanic membranes is comparable (typically 12 kPa), but the microstructured patches are easier to handle by the surgeon. For the first time, partial recovery of hearing performance is measured immediately after patch application. The novel patches adhere without the need for further fixation, removing the need for ear canal packing. The proposed material design holds great promise for improving clinical treatments of tympanic membrane perforations.
- Subjects :
- Materials science
02 engineering and technology
010402 general chemistry
01 natural sciences
microstructured adhesives
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Silicone
otorhinolaryngologic diseases
Medical technology
Composite material
R855-855.5
030223 otorhinolaryngology
silicone patches
Tympanic Membrane Perforation
General Environmental Science
021001 nanoscience & nanotechnology
0104 chemical sciences
Membrane
Self adhesive
tympanic membrane perforations
chemistry
distortion product otoacoustic emissions
General Earth and Planetary Sciences
0210 nano-technology
TP248.13-248.65
Biotechnology
Subjects
Details
- ISSN :
- 26999307
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Advanced NanoBiomed Research
- Accession number :
- edsair.doi.dedup.....eec9ee31d24eb006ed3f329d9eda0d09