Low neural exosomal levels of cellular survival factors in Alzheimer's disease

Authors :: Maja Mustapić
Janice B. Schwartz
Olga D. Carlson
Adam L. Boxer
Edward J. Goetzl
Erin L. Abner
Bruce L. Miller
Ronald C. Petersen
Dimitrios Kapogiannis
Source :: Annals of Clinical and Translational Neurology, Annals of clinical and translational neurology, vol 2, iss 7, Goetzl, EJ; Boxer, A; Schwartz, JB; Abner, EL; Petersen, RC; Miller, BL; et al.(2015). Low neural exosomal levels of cellular survival factors in Alzheimer's disease. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2(7), 769-773. doi: 10.1002/acn3.211. UCSF: Retrieved from: http://www.escholarship.org/uc/item/0j1112kj
Publication Year :: 2015
Publisher :: Wiley, 2015.
Abstract: Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P&nbsp

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