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Inflammatory dendritic cells in mice and humans
- Source :
- Trends in Immunology, Trends in Immunology, Elsevier, 2013, 34 (9), pp.440-5. ⟨10.1016/j.it.2013.06.001⟩, Trends in Immunology, Elsevier, 2013, 34 (9), pp.440-5. 〈10.1016/j.it.2013.06.001〉
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells. Several murine DC subsets have been identified that differ in their phenotype and functional properties. In the steady state, DC precursors originating from the bone marrow give rise to lymphoid-organ-resident DCs and to migratory tissue DCs. During inflammation, an additional DC subset has been described, so-called inflammatory DCs (infDCs), which differentiate from monocytes recruited to the site of inflammation. Here, we review recent work on the development and functions of murine infDCs. We also examine the criteria that define infDCs. Finally, we discuss the characterization of human infDCs and their potential role in inflammatory diseases.
- Subjects :
- MESH: Cell Differentiation
MESH: Inflammation
[SDV.IMM] Life Sciences [q-bio]/Immunology
Immunology
Inflammation
Lymphocyte Activation
MESH: Monocytes
Monocytes
Mice
03 medical and health sciences
0302 clinical medicine
MESH : Mice
Animals
Humans
Immunology and Allergy
Medicine
[ SDV.IMM ] Life Sciences [q-bio]/Immunology
MESH: Animals
dendritic cells
MESH: Lymphocyte Activation
MESH: Mice
MESH : Lymphocyte Activation
030304 developmental biology
0303 health sciences
MESH : Inflammation
MESH: Humans
Follicular dendritic cells
MESH: Dendritic Cells
business.industry
MESH : Humans
Cell Differentiation
Phenotype
3. Good health
Heterogeneous population
medicine.anatomical_structure
MESH : Monocytes
inflammation
MESH : Dendritic Cells
[SDV.IMM]Life Sciences [q-bio]/Immunology
Bone marrow
MESH : Animals
medicine.symptom
business
MESH : Cell Differentiation
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 14714906
- Database :
- OpenAIRE
- Journal :
- Trends in Immunology, Trends in Immunology, Elsevier, 2013, 34 (9), pp.440-5. ⟨10.1016/j.it.2013.06.001⟩, Trends in Immunology, Elsevier, 2013, 34 (9), pp.440-5. 〈10.1016/j.it.2013.06.001〉
- Accession number :
- edsair.doi.dedup.....eec283d12753d3523e6935cd071b1cab