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YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin E
- Source :
- European Respiratory Journal. 35:757-760
- Publication Year :
- 2010
- Publisher :
- European Respiratory Society (ERS), 2010.
-
Abstract
- The chitinase-like protein YKL-40, which binds chitin but lacks chitinase activity, has been found to be either the cause or a biomarker for asthma. The aim of our study was to investigate whether serum YKL-40 levels are increased in Chinese patients with asthma and identify its correlation to acute exacerbation, total serum immunoglobulin (Ig)E, the percentage of peripheral blood eosinophils and lung function. We quantified serum YKL-40 levels, total IgE levels and peripheral blood eosinophil percentages in patients with asthma, as well as in controls from the communities surrounding our hospital. The lung function of asthma subjects was also measured. Our data showed that the serum YKL-40 levels were significantly elevated in patients with asthma compared with controls and, when the asthma subjects were stratified, serum YKL-40 levels in the exacerbation group were higher than those in the stable and control groups. In addition, serum YKL-40 levels correlated positively with total serum IgE levels and the percentage of peripheral blood eosinophils, but correlated inversely with lung functions. Thus, we conclude that YKL-40 is found in increased quantities in the serum of Chinese patients with asthma, and its level correlates with exacerbation attacks, indicating that high levels of serum YKL-40 may be a biological characteristic of the exacerbation of asthma.
- Subjects :
- Male
musculoskeletal diseases
Pulmonary and Respiratory Medicine
Adolescent
Exacerbation
Immunoglobulin E
CHI3L1
Young Adult
Adipokines
Asian People
Forced Expiratory Volume
Lectins
medicine
Humans
Chitinase-3-Like Protein 1
Child
Aged
Glycoproteins
Asthma
biology
business.industry
Respiratory disease
Middle Aged
Eosinophil
medicine.disease
respiratory tract diseases
Eosinophils
medicine.anatomical_structure
Case-Control Studies
Acute Disease
Immunology
biology.protein
Female
Antibody
business
Subjects
Details
- ISSN :
- 13993003 and 09031936
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- European Respiratory Journal
- Accession number :
- edsair.doi.dedup.....eec03d6e174f42bc826c677297407e2f