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The profile of lipid metabolites in urine of marmoset wasting syndrome

Authors :
Rikako Inoue
Hiroki Ohta
Hirotaka James Okano
Nanae Nagata
Takako Miyabe-Nishiwaki
Koji Kobayashi
Tatsuro Nakamura
Takahisa Murata
Yuta Hamasaki
Akiyo Ishigami
Yusuke Miyazaki
Akihisa Kaneko
Makoto Koizumi
Arisa Yamazaki
Akihiro Hirata
Source :
PLoS ONE, Vol 15, Iss 6, p e0234634 (2020), PLoS ONE
Publication Year :
2020
Publisher :
Public Library of Science (PLoS), 2020.

Abstract

Marmoset wasting syndrome (MWS) is clinically characterized by progressive weight loss. Although morbidity and mortality of MWS are relatively high in captive marmosets, its causes remain unknown. Lipid mediators are bioactive metabolites which are produced from polyunsaturated fatty acids, such as arachidonic acid (AA) and eicosapentaenoic acid. These lipid metabolites regulate a wide range of inflammatory responses and they are excreted into the urine. As urinary lipid profiles reflect systemic inflammatory conditions, we comprehensively measured the levels of 141 types of lipid metabolites in the urines obtained from healthy common marmoset (Callithrix jacchus) (N = 7) or marmosets with MWS (N = 7). We found that 41 types of metabolites were detected in all urine samples of both groups. Among them, AA-derived metabolites accounted for 63% (26/41 types) of all detected metabolites. Notably, the levels of AA-derived prostaglandin (PG) E2, PGF2α, thromboxane (TX) B2 and F2-isoprostanes significantly increased in the urine samples of marmosets with MWS. In this study, we found some urinary lipid metabolites which may be involved in the development of MWS. Although the cause of MWS remains unclear, our findings may provide some insight into understanding the mechanisms of development of MWS.

Details

ISSN :
19326203
Volume :
15
Database :
OpenAIRE
Journal :
PLOS ONE
Accession number :
edsair.doi.dedup.....eebfa779500e50585f04c2610d02c33c
Full Text :
https://doi.org/10.1371/journal.pone.0234634