Re-evaluation of direct hemoperfusion with polymyxin-B immobilized fiber for severe sepsis and septic shock

The equivalency of continuous venovenous hemofiltration and intermittent hemodialysis (2B) was described as a key recommendation of the Surviving Sepsis Campaign guidelines in 2008. However, there are some discrepancies associated with the evaluation of blood purification in severe sepsis and septic shock in Japan. Direct hemoperfusion with polymyxin-B immobilized fiber (PMX-DHP), developed and currently in use in Japan, has not yet been evaluated abroad. We performed a retrospective study to re-evaluate PMX-DHP for severe sepsis or septic shock patients in our ICU.