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Antipanic drug modulation of 35% CO2 hyperreactivity and short-term treatment outcome
- Publication Year :
- 2002
-
Abstract
- Carbon dioxide (CO2) inhalation induces acute anxiety and panic attacks in patients with Panic Disorder (PD). Anti-panic drugs decrease CO2 reactivity after the first days of treatment; however, the clinical meaning of this finding has not yet been established. This study investigated the effects of treatment with tricyclic antidepressants and selective serotonin re-uptake inhibitors (SSRIs) on CO2 reactivity and compared the relationships between 35% CO2 hyperreactivity modulation and short-term clinical outcome. One hundred twenty-three patients with PD with or without agoraphobia who were hyperreactive to CO2 were randomly assigned to treatment groups with imipramine, clomipramine, paroxetine, sertraline, or fluvoxamine. A double-blind, randomized design was applied. Each patient received the 35% CO2 challenge on days 0, 7, and 30. The severity of clinical symptomatology was measured on days 0 and 30. Decreased hyperreactivity to 35% CO2 in all five treatment groups was already evident after the first week. The decrease in CO2 reactivity at the end of treatment was proportional to the degree of clinical improvement. Multiple regression analyses showed that the decrease in CO2 reactivity after the first week was a significant predictor for good clinical outcome after one month. The results of this study confirm evidence that psychoactive drugs effective in the treatment of PD decrease CO2 hyperreactivity. They also suggest that precocious modulation of CO2 reactivity might fairly reliably predict short-term clinical outcome in patients with "respiratory" PD.
- Subjects :
- Adult
Male
Clomipramine
medicine.medical_specialty
Fluvoxamine
Antidepressive Agents, Tricyclic
Imipramine
Gastroenterology
Statistics, Nonparametric
Internal medicine
medicine
Humans
Pharmacology (medical)
Agoraphobia
Sertraline
Chi-Square Distribution
Panic disorder
Panic
Carbon Dioxide
Middle Aged
medicine.disease
Paroxetine
Psychiatry and Mental health
Treatment Outcome
Anesthesia
Panic Disorder
Female
Bronchial Hyperreactivity
medicine.symptom
Psychology
Selective Serotonin Reuptake Inhibitors
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....eead3e320bf48f13b2673805925c319a