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CT findings during phase of accelerated deterioration in patients with idiopathic pulmonary fibrosis
- Source :
- AJR. American journal of roentgenology. 168(1)
- Publication Year :
- 1997
-
Abstract
- Most patients with idiopathic pulmonary fibrosis (IPF) show slowly progressive deterioration. However, accelerated deterioration also occurs in patient with IPF who have previously shown slowly progressive deterioration. The purpose of this study was to evaluate the CT findings of accelerated deterioration in patients with IPF.We evaluated the CT findings of 17 patients with IPF who fulfilled all the following criteria for accelerated deterioration of IPF: exacerbation of dyspnea within 1 month, new diffuse pulmonary opacities on chest radiography, a decrease in arterial oxygen tension (PaO2) of more than 10 mm Hg under similar conditions, and absence of apparent infectious agents and heart failure. Seven patients underwent sequential CT examination. Pathologic specimens were obtained from nine patients.CT findings were classified as peripheral parenchymal opacification (n = 6), multifocal parenchymal opacification (n = 6), and diffuse parenchymal opacification (n = 5). Multifocal lesions developed diffusely in two of the seven patients who underwent sequential CT. These two patients both died. Three of the six patients with a multifocal pattern responded to corticosteroid therapy. All patients with a peripheral pattern showed various degrees of improvement following corticosteroid therapy. Multifocal and diffuse parenchymal opacification corresponded pathologically to acute diffuse alveolar damage. Peripheral parenchymal opacification corresponded pathologically to active fibroblastic foci.CT patterns seen during periods of rapid deterioration in patients with IPF may allow predictions of prognosis and of response to treatment.
- Subjects :
- Male
medicine.medical_specialty
Exacerbation
Radiography
Pulmonary Fibrosis
Methylprednisolone
Idiopathic pulmonary fibrosis
Fibrosis
Medicine
Humans
Radiology, Nuclear Medicine and imaging
In patient
Glucocorticoids
Lung
Aged
business.industry
Respiratory disease
General Medicine
respiratory system
Middle Aged
medicine.disease
Prognosis
respiratory tract diseases
medicine.anatomical_structure
Heart failure
Female
Radiology
business
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 0361803X
- Volume :
- 168
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- AJR. American journal of roentgenology
- Accession number :
- edsair.doi.dedup.....eea76dc5d04bd10abd496375deada67d