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Combined associations of a polygenic risk score and classical risk factors with breast cancer risk
- Source :
- JNCI Journal of the National Cancer Institute, ABCTB Investigators 2020, ' Combined associations of a polygenic risk score and classical risk factors with breast cancer risk ', Journal of the National Cancer Institute . https://doi.org/10.1093/jnci/djaa056, Repisalud, Instituto de Salud Carlos III (ISCIII), Kapoor, P M, Mavaddat, N, Choudhury, P P, Wilcox, A N, Lindström, S, Behrens, S, Michailidou, K, Dennis, J, Bolla, M K, Wang, Q, Jung, A, Abu-Ful, Z, Ahearn, T, Andrulis, I L, Anton-Culver, H, Arndt, V, Aronson, K J, Auer, P L, Freeman, L E B, Becher, H, Beckmann, M W, Beeghly-Fadiel, A, Benitez, J, Bernstein, L, Bojesen, S E, Brauch, H, Brenner, H, Brüning, T, Cai, Q, Campa, D, Canzian, F, Carracedo, A, Carter, B D, Castelao, J E, Chanock, S J, Chatterjee, N, Chenevix-Trench, G, Clarke, C L, Couch, F J, Cox, A, Cross, S S, Czene, K, Dai, J Y, Earp, H S, Ekici, A B, Eliassen, A H, Eriksson, M, Evans, D G, Fasching, P A, Scott, C, ABCTB Investigators & kConFab/AOCS Investigators 2021, ' Combined Associations of a Polygenic Risk Score and Classical Risk Factors with Breast Cancer Risk ', Journal of the National Cancer Institute, vol. 113, no. 3, pp. 329-337 . https://doi.org/10.1093/jnci/djaa056, 2020, ' Combined associations of a polygenic risk score and classical risk factors with breast cancer risk ', Journal of the National Cancer Institute (JNCI) . https://doi.org/10.1093/jnci/djaa056, JNCI: Journal of the National Cancer Institute
- Publication Year :
- 2020
-
Abstract
- We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer. ispartof: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE vol:113 issue:3 pages:329-337 ispartof: location:United States status: published
- Subjects :
- Cancer Research
Epidemiology
Gene-environment interactions
Logistic regression
Body Mass Index
0302 clinical medicine
Breast cancer
Medicine
10. No inequality
Medical History Taking
Estrogen Receptor Status
Aged, 80 and over
0303 health sciences
Middle Aged
Risk prediction
3. Good health
Oncology
Receptors, Estrogen
030220 oncology & carcinogenesis
Female
AcademicSubjects/MED00010
Medical Genetics
medicine.medical_specialty
Breast Neoplasms
Brief Communication
Polymorphism, Single Nucleotide
White People
Genetic susceptibility
Polygenic risk score
Risk factors
03 medical and health sciences
SDG 3 - Good Health and Well-being
Humans
Genetic Predisposition to Disease
Risk factor
Medicinsk genetik
030304 developmental biology
Aged
Cancer och onkologi
business.industry
Case-control study
Cancer
Odds ratio
medicine.disease
Logistic Models
Cancer and Oncology
Case-Control Studies
business
Demography
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- JNCI Journal of the National Cancer Institute, ABCTB Investigators 2020, ' Combined associations of a polygenic risk score and classical risk factors with breast cancer risk ', Journal of the National Cancer Institute . https://doi.org/10.1093/jnci/djaa056, Repisalud, Instituto de Salud Carlos III (ISCIII), Kapoor, P M, Mavaddat, N, Choudhury, P P, Wilcox, A N, Lindström, S, Behrens, S, Michailidou, K, Dennis, J, Bolla, M K, Wang, Q, Jung, A, Abu-Ful, Z, Ahearn, T, Andrulis, I L, Anton-Culver, H, Arndt, V, Aronson, K J, Auer, P L, Freeman, L E B, Becher, H, Beckmann, M W, Beeghly-Fadiel, A, Benitez, J, Bernstein, L, Bojesen, S E, Brauch, H, Brenner, H, Brüning, T, Cai, Q, Campa, D, Canzian, F, Carracedo, A, Carter, B D, Castelao, J E, Chanock, S J, Chatterjee, N, Chenevix-Trench, G, Clarke, C L, Couch, F J, Cox, A, Cross, S S, Czene, K, Dai, J Y, Earp, H S, Ekici, A B, Eliassen, A H, Eriksson, M, Evans, D G, Fasching, P A, Scott, C, ABCTB Investigators & kConFab/AOCS Investigators 2021, ' Combined Associations of a Polygenic Risk Score and Classical Risk Factors with Breast Cancer Risk ', Journal of the National Cancer Institute, vol. 113, no. 3, pp. 329-337 . https://doi.org/10.1093/jnci/djaa056, 2020, ' Combined associations of a polygenic risk score and classical risk factors with breast cancer risk ', Journal of the National Cancer Institute (JNCI) . https://doi.org/10.1093/jnci/djaa056, JNCI: Journal of the National Cancer Institute
- Accession number :
- edsair.doi.dedup.....eea761d2fa17724912d4220630c4ead2