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Dietary Bioactive Fatty Acids as Modulators of Immune Function: Implications on Human Health
- Source :
- Nutrients
- Publication Year :
- 2019
-
Abstract
- Diet is major modifiable risk factor for cardiovascular disease that can influence the immune status of the individual and contribute to persistent low-grade inflammation. In recent years, there has been an increased appreciation of the role of polyunsaturated fatty acids (PUFA) in improving immune function and reduction of systemic inflammation via the modulation of pattern recognition receptors (PRR) on immune cells. Extensive research on the use of bioactive lipids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and their metabolites have illustrated the importance of these pro-resolving lipid mediators in modulating signaling through PRRs. While their mechanism of action, bioavailability in the blood, and their efficacy for clinical use forms an active area of research, they are found widely administered as marine animal-based supplements like fish oil and krill oil to promote health. The focus of this review will be to discuss the effect of these bioactive fatty acids and their metabolites on immune cells and the resulting inflammatory response, with a brief discussion about modern methods for their analysis using mass spectrometry-based methods.
- Subjects :
- 0301 basic medicine
Docosahexaenoic Acids
Inflammation
Receptors, Cell Surface
Health Promotion
Review
Immune function
toll like receptors
essential fatty acids
030204 cardiovascular system & hematology
Pharmacology
Lymphocyte Activation
Krill oil
PPAR
03 medical and health sciences
0302 clinical medicine
Immune system
Fish Oils
Dietary Fats, Unsaturated
FDA regulations
Medicine
Humans
chemistry.chemical_classification
Nutrition and Dietetics
business.industry
Pattern recognition receptor
Immunity
EPA
Fish oil
Eicosapentaenoic acid
3. Good health
DHA
030104 developmental biology
chemistry
Eicosapentaenoic Acid
Docosahexaenoic acid
Dietary Supplements
non-essential fatty acids
Fatty Acids, Unsaturated
Cytokines
medicine.symptom
business
Food Science
Polyunsaturated fatty acid
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 11
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....eea6ddcbb21a1f052b2af4949e82178e