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Efficacy of ribavirin and interferon-α therapy for hospitalized patients with COVID-19: A multicenter, retrospective cohort study
- Source :
- International Journal of Infectious Diseases, Vol 104, Iss, Pp 641-648 (2021), International Journal of Infectious Diseases
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Highlights • There is currently no specific antiviral therapy for patients with COVID-19. • Ribavirin and interferon-α were clinically used as repurposed antiviral drugs. • RBV/IFN-α therapy was not observed to any benefit in improving patient outcomes. • In contrast, inappropriate timing of interferon-α might prolong the hospital stay. • Looking for an effective response to COVID-19 is the focus of the current task.<br />Objective To assess the efficacy and safety of ribavirin and interferon-α (RBV/IFN-α) therapy in patients with COVID-19. Methods This multi-center, retrospective cohort study included patients with COVID-19 admitted to four hospitals in Hubei Province, China, from 31 December, 2019 to 31 March, 2020. Patients were divided into two groups according to their exposure to RBV/IFN-α therapy within 48 hours of admission. Mixed-effect Cox model and Logistic regression were used to explore the association between early treatments of RBV/IFN-α with primary outcomes. Results Of 2037 patients eventually included, 1281 patients received RBV/IFN-α (RBV alone/IFN-α alone/RBV combined with IFN-α) treatments and 756 patients received none of these treatments. In mixed effect model, RBV/IFN-α therapy was not associated with progression from non-severe into severe type (aHR = 1.09, 95%CI: 0.88-1.36) or with reduction in 30-day mortality (aHR = 0.89, 95%CI: 0.61-1.30). However, it was associated with a higher probability of length of hospital stay over 15 days (aOR = 2.11, 95%CI: 1.68-2.64) compared with No RBV/IFN-α therapy. Moreover, the propensity score-matched cohort and subgroup analysis displayed similar results. Conclusion RBV/IFN-α therapy was not observed to any benefit in improving clinical outcomes in patients with COVID-19, suggesting that RBV/IFN-α therapy should be avoided in COVID-19 patients.
- Subjects :
- 0301 basic medicine
Adult
Male
Microbiology (medical)
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
030106 microbiology
Subgroup analysis
Antiviral therapy
Logistic regression
Antiviral Agents
Article
lcsh:Infectious and parasitic diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Interferon α
Ribavirin
medicine
Humans
lcsh:RC109-216
030212 general & internal medicine
Aged
Retrospective Studies
Proportional hazards model
business.industry
SARS-CoV-2
Interferon-alpha
COVID-19
Retrospective cohort study
General Medicine
Middle Aged
COVID-19 Drug Treatment
Infectious Diseases
chemistry
Cohort
Cohort studies
Drug Therapy, Combination
Female
business
Interferon-α
Subjects
Details
- Language :
- English
- ISSN :
- 12019712
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- International Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....eea49019f2c1f6dd0c26282c07213e77