Back to Search
Start Over
Association of A1C with cardiovascular disease and metabolic syndrome in Asian Indians with normal glucose tolerance
- Source :
- Diabetes care. 30(6)
- Publication Year :
- 2007
-
Abstract
- OBJECTIVE—This study examines the association of A1C with cardiovascular disease (CVD) risk factors, coronary artery disease (CAD), and metabolic syndrome in Asian Indians with normal glucose tolerance (NGT). RESEARCH DESIGN AND METHODS—This cross-sectional study recruited subjects from phase III of the Chennai Urban Rural Epidemiology Study (CURES), an epidemiological study in a representative population of Chennai (formerly Madras) in South India, conducted between January 2003 and June 2004. Included were 1,644 subjects with NGT, i.e., fasting plasma glucose RESULTS—The mean ± SD A1C value in the study cohort was 5.5 ± 0.4%. A1C showed a significant association with BMI (β = 0.017, P < 0.001), systolic (β = 0.002, P = 0.028) and diastolic (β = 0.202, P = 0.017) blood pressure, waist circumference (β = 0.007, P < 0.001), serum cholesterol (β = 0.002, P < 0.001), triglycerides (β = 0.001, P < 0.001), LDL cholesterol (β = 0.002, P < 0.001), fasting insulin (β = 0.009, P < 0.001), and homeostasis model assessment of insulin resistance (β = 0.047, P < 0.001) after adjusting for age and sex. Regression analysis showed that A1C had a strong association with metabolic syndrome that persisted after adjusting for age and sex (odds ratio [OR] 2.9 [95% CI 2.08–4.00]; P < 0.001). A1C also had a strong association with CAD (2.6 [1.23–5.63]; P = 0.01), but the significance was lost when adjusted for age and sex. CONCLUSIONS—There is a strong association of A1C with prevalent CVD risk factors in Asian-Indian subjects with NGT.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Waist
Cross-sectional study
Endocrinology, Diabetes and Metabolism
Population
India
Coronary Disease
Cohort Studies
Asian People
Reference Values
Diabetes mellitus
Internal medicine
Epidemiology
Internal Medicine
medicine
Body Size
Humans
education
Advanced and Specialized Nursing
Glycated Hemoglobin
Metabolic Syndrome
education.field_of_study
Analysis of Variance
business.industry
Middle Aged
medicine.disease
Endocrinology
Cross-Sectional Studies
Cardiovascular Diseases
Cohort
Female
Metabolic syndrome
business
Cohort study
Subjects
Details
- ISSN :
- 19355548
- Volume :
- 30
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Diabetes care
- Accession number :
- edsair.doi.dedup.....ee8b9c5d77122592113ef0be4bb54cf8