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Alpha-Fetoprotein-Producing Rectal Carcinoma. A Case Report
- Source :
- The Kurume Medical Journal. 44:339-348
- Publication Year :
- 1997
- Publisher :
- Kurume Medical Journal, 1997.
-
Abstract
- A case with an alpha-fetoprotein (AFP)-producing carcinoma originating from the rectum is described. A 71-year-old male patient, who underwent a rectectomy for rectal carcinoma, developed space occupying lesions in the liver and a remarkable AFP elevation (220,000 ng/ml) in the 6th month postoperatively, and then expired one year later. Histologically, the rectal carcinoma consisted of well-differentiated adenocarcinomas, and contiguous cancerous cells proliferating in either a medullary or trabecular pattern. In the "trabecular" areas, localization of AFP was confirmed immunohistochemically. Results of concanavalin A or lens culinaris agglutinin affinity chromatography demonstrated that it was between a hepatic type and a yolk sac type, and was considered to be an intestinal type. This could have been an AFP-producing rectal carcinoma, in which the patient experienced liver metastasis at a relatively early postoperative period and died. This shows that AFP-producing rectal carcinomas are highly malignant, biologically, similar to AFP-producing gastric cancers.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Medullary cavity
Rectal Neoplasms
Liver Neoplasms
Rectum
General Medicine
Adenocarcinoma
Biology
medicine.disease
digestive system diseases
Metastasis
medicine.anatomical_structure
Trabecular Pattern
embryonic structures
medicine
Carcinoma
Humans
alpha-Fetoproteins
Yolk sac
Alpha-fetoprotein
Aged
Subjects
Details
- ISSN :
- 18812090 and 00235679
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- The Kurume Medical Journal
- Accession number :
- edsair.doi.dedup.....ee8acef6266746eaeb434dc3cad1fa6e