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The Glu298Asp polymorphism in the endothelial nitric oxide synthase gene is strongly associated with coronary spasm
- Source :
- Coronary Artery Disease. 14:293-299
- Publication Year :
- 2003
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2003.
-
Abstract
- Background Coronary spasm seems to be associated with coronary nitric oxide deficiency. Objectives We investigated whether the Glu298Asp polymorphism in the endothelial nitric oxide synthase (eNOS) gene is a definite risk factor for coronary spasm and whether diffuse spasm involving normal-looking coronary artery correlates significantly with the Glu298Asp polymorphism, in contrast with focal spasm superimposed on an atherosclerotic plaque. Methods A polymerase chain reaction followed by restriction fragment length polymorphism analysis was performed in 118 control participants and in 102 patients with variant angina and a similar degree of atherosclerotic burden. Patients with coronary spasm were divided into diffuse spasm and focal spasm subgroups according to morphological criteria. Results There was a significantly higher incidence of the Glu298Asp polymorphism in the coronary spasm group than in the control group (21.5% compared with 8.5%,P=0.006). Multiple logistic regression analysis using risk factors and the Glu298Asp polymorphism showed that the most important predictive factor for coronary spasm was the Glu298Asp polymorphism (odds ratio 2.83, 95% confidence interval 1.25-6.41,P= 0.009). The diffuse spasm subgroup had a significantly higher frequency of the Glu298Asp polymorphism than the control group (25.9% compared with 8.5%,P= 0.002). However, the focal spasm subgroup did not differ from the control group in the frequency of Glu298Asp polymorphism. Conclusion The Glu298Asp polymorphism in the eNOS gene is a definite risk factor for coronary spasm, especially for diffuse coronary spasm. This result supports the notion that diffuse coronary spasm is significantly associated with endothelial dysfunction, in contrast to focal spasm.Coron Artery Dis14:293-299 © 2003 Lippincott Williams & Wilkins.
- Subjects :
- Genetic Markers
Male
medicine.medical_specialty
Genotype
Nitric Oxide Synthase Type III
Mutation, Missense
Coronary Vasospasm
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Nitric oxide
Angina
chemistry.chemical_compound
Risk Factors
Enos
Internal medicine
otorhinolaryngologic diseases
medicine
Humans
Genetic Predisposition to Disease
cardiovascular diseases
Endothelial dysfunction
biology
business.industry
General Medicine
Odds ratio
Middle Aged
medicine.disease
biology.organism_classification
nervous system diseases
body regions
Nitric oxide synthase
stomatognathic diseases
Logistic Models
medicine.anatomical_structure
chemistry
Coronary vasospasm
Cardiology
biology.protein
Female
Nitric Oxide Synthase
Cardiology and Cardiovascular Medicine
business
Artery
Subjects
Details
- ISSN :
- 09546928
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Coronary Artery Disease
- Accession number :
- edsair.doi.dedup.....ee8778efa7e7cf99f164c5eee8cfe2eb