Back to Search
Start Over
Exercise capacity and muscle fatiguability alterations following a progressive maximal exercise of lower extremities in children with cystic fibrosis
- Source :
- African Health Sciences, African Health Sciences; Vol 18, No 4 (2018); 1236-1242
- Publication Year :
- 2018
- Publisher :
- Makerere Medical School, 2018.
-
Abstract
- Background: Impairment of peripheral skeletal muscle function is a common phenomenon in patients with cystic fibrosis (CF) in addition to great clinical connotations, such as lack of exercise tolerance and decrease of health-related quality of life. There is very limited data on the effects of maximal exercise on muscle fatiguability and exercise capacity in children with cystic fibrosis. Objectives: The aim of this study was to evaluate the effect of progressive maximal exercise training of the lower extremities on exercise capacity and muscle fatiguability in children with cystic fibrosis.Study design: Between June and September 2017, eighteen children aged 8-12 years were recruited in this study. This study had two groups of children; the CF group consisted of nine children (6 males and 3 females) with cystic fibrosis and the control group consisted of nine healthy age matched children (6 males and 3 females). The children underwent a progressive maximal cardiopulmonary exercise cycling test (CPET), muscle fatigue test, and magnetic resonance imaging (MRI) to measure a muscle cross-section area (CSA). Also, pulmonary functions were assessed.Results: The findings of this study showed that the CF children had less pulmonary functions, had a less exercise capacity, and had a higher breathing reserve index and oxygen desaturation when compared with healthy children (p0.05). Conclusion: This study indicates that progressive maximal exercise doesn’t affect muscle fatiguability, muscle cross-section area, and maximal voluntary contraction in CF children with moderate respiratory diseases but includes lower exercise capacity. CF children and healthy age matched children have similar responses to maximal exercise in muscle fatiguability, muscle cross-section area, and maximal voluntary contractions but lower exercise capacity in the CF group.Keywords: Cystic fibrosis, children, lower extremities, exercise capacity, muscle fatiguability.
- Subjects :
- Male
medicine.medical_specialty
Cystic Fibrosis
Cystic fibrosis
03 medical and health sciences
0302 clinical medicine
Oxygen Consumption
Quality of life
children
Heart Rate
Internal medicine
medicine
Humans
030212 general & internal medicine
Respiratory system
Child
Muscle, Skeletal
Exercise Tolerance
Muscle fatigue
medicine.diagnostic_test
lower extremities
business.industry
Skeletal muscle
Magnetic resonance imaging
General Medicine
Articles
medicine.disease
Magnetic Resonance Imaging
Exercise Therapy
Respiratory Function Tests
exercise capacity
Oxygen
medicine.anatomical_structure
030228 respiratory system
Lower Extremity
Cystic fibrosis, children, lower extremities, exercise capacity, muscle fatiguability
Muscle Fatigue
Breathing
Cardiology
Exercise Test
Quality of Life
Fatiguability
Female
business
muscle fatiguability
Subjects
Details
- Language :
- English
- ISSN :
- 17290503 and 16806905
- Volume :
- 18
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- African Health Sciences
- Accession number :
- edsair.doi.dedup.....ee85dca0763bed18750bd7fe2fee5b2f