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Clear cell carcinomas of the ovary have poorer outcomes compared with serous carcinomas: Results from a single-center Taiwanese study
- Source :
- Journal of the Formosan Medical Association, Vol 117, Iss 2, Pp 117-125 (2018)
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- Background/purpose To compare the clinical outcomes of Taiwanese patients with ovarian clear cell carcinomas (CCCs) and serous carcinomas (SCs). Methods We retrieved the clinical records of women with epithelial ovarian cancer (Stage I–IV) who received primary surgeries between 2000 and 2013. Cancer-specific survival (CSS), progression-free survival, and survival after recurrence (SAR) of CCC and SC patients were retrospectively compared. Multivariate analysis was used to identify the independent predictors of survival. Results Of 891 women diagnosed with epithelial ovarian cancer, 169 CCCs and 351 high-grade SCs were analyzed. The 5-year CSS rates of CCC patients were significantly lower than those of SC for both Stage III (22.3% vs. 47.3%, p = 0.001) and Stage IV (0% vs. 24.4%, p = 0.001) disease. In the absence of gross residual malignancies, the 5-year CSS rate was better for CCC (82.3%) than SC (75.2%, p = 0.010). The 5-year SAR rate was significantly lower for CCC than SC (14.3% vs. 24.4%, p = 0.002). Old age and residual malignancies were independent prognostic factors for CSS in the entire cohort of CCC patients. In the subgroup of Stage I CCC, positive cytology was identified as the only adverse prognostic factor for CSS. Conclusion The clinical outcomes of CCC are generally poorer than SC. Complete cytoreduction to no gross residual disease should be ideally achieved in CCC patients. A greater understanding of the molecular pathogenesis of CCC may lead to tailored therapies, ultimately optimizing outcomes.
- Subjects :
- 0301 basic medicine
Oncology
Adult
medicine.medical_specialty
Multivariate analysis
Neoplasm, Residual
Adolescent
Taiwan
ovarian epithelial cancer
Ovary
Carcinoma, Ovarian Epithelial
Single Center
03 medical and health sciences
Young Adult
0302 clinical medicine
Internal medicine
Medicine
Humans
Neoplasms, Glandular and Epithelial
Clear-cell adenocarcinoma
Stage (cooking)
Aged
Neoplasm Staging
Retrospective Studies
Gynecology
Aged, 80 and over
Ovarian Neoplasms
lcsh:R5-920
business.industry
serous adenocarcinoma
General Medicine
Middle Aged
clear cell adenocarcinoma
medicine.disease
Survival Analysis
residual neoplasm
Cystadenocarcinoma, Serous
Serous fluid
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cohort
Multivariate Analysis
Female
prognosis
business
lcsh:Medicine (General)
Clear cell
Adenocarcinoma, Clear Cell
Subjects
Details
- Language :
- English
- ISSN :
- 09296646
- Volume :
- 117
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of the Formosan Medical Association
- Accession number :
- edsair.doi.dedup.....ee820626f66f5535e391c9399f8a24dc