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Mitogenic proteinases from human leukocytes
- Source :
- Molecular Immunology. 21:311-320
- Publication Year :
- 1984
- Publisher :
- Elsevier BV, 1984.
-
Abstract
- Serine proteinase activity has been identified in purified human lymphocyte membranes, and the corresponding enzymes have been isolated from human leukocyte extracts by affinity chromatography. The localization of these enzymes on lymphocyte and granulocyte membranes has been immunochemically demonstrated. Mitogenic activity towards human lymphocytes has been demonstrated for these enzymes, and anti proteinase antibodies inhibit the growth of transformed lymphocytes. The proteinases are similar in many properties to enzymes previously isolated from human leukocytes, and reported to be involved in a wide variety of leukocyte functions.
- Subjects :
- Lymphocyte
Immunology
Biology
Granulocyte
Chromatography, Affinity
Serine
Affinity chromatography
Endopeptidases
Leukocytes
medicine
Humans
Lymphocytes
Molecular Biology
chemistry.chemical_classification
Cell Membrane
Biological activity
Molecular biology
Enzyme
medicine.anatomical_structure
chemistry
Biochemistry
Mitogen-activated protein kinase
biology.protein
Mitogens
Antibody
Cell Division
Granulocytes
Subjects
Details
- ISSN :
- 01615890
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Molecular Immunology
- Accession number :
- edsair.doi.dedup.....ee81cb6082681097f172cb3a4e7c7df6