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Image-Guided Peri-Tumoral Radiofrequency Hyperthermia-Enhanced Direct Chemo-Destruction of Hepatic Tumor Margins
Image-Guided Peri-Tumoral Radiofrequency Hyperthermia-Enhanced Direct Chemo-Destruction of Hepatic Tumor Margins
- Source :
- Frontiers in Oncology, Frontiers in Oncology, Vol 11 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- PurposeTo validate the feasibility of using peri-tumoral radiofrequency hyperthermia (RFH)-enhanced chemotherapy to obliterate hepatic tumor margins.Method and MaterialsThis study included in vitro experiments with VX2 tumor cells and in vivo validation experiments using rabbit models of liver VX2 tumors. Both in vitro and in vivo experiments received different treatments in four groups (n=6/group): (i) RFH-enhanced chemotherapy consisting of peri-tumoral injection of doxorubicin plus RFH at 42°C; (ii) RFH alone; (iii) doxorubicin alone; and (iv) saline. Therapeutic effect on cells was evaluated using different laboratory examinations. For in vivo experiments, orthotopic hepatic VX2 tumors in 24 rabbits were treated by using a multipolar radiofrequency ablation electrode, enabling simultaneous delivery of both doxorubicin and RFH within the tumor margins. Ultrasound imaging was used to follow tumor growth overtime, correlated with subsequent histopathological analysis.ResultsIn in vitro experiments, MTS assay demonstrated the lowest cell proliferation, and apoptosis analysis showed the highest apoptotic index with RFH-enhanced chemotherapy, compared with the other three groups (pin vivo experiments, ultrasound imaging detected the smallest relative tumor volume with RFH-enhanced chemotherapy (pConclusionThis study demonstrates that peri-tumoral RFH can specifically enhance the destruction of tumor margins in combination with peri-tumoral injection of a chemotherapeutic agent. This new interventional oncology technique may address the critical clinical problem of frequent marginal tumor recurrence/persistence following thermal ablation of large (>3 cm) hepatic cancers.
- Subjects :
- Hyperthermia
Cancer Research
Pathology
medicine.medical_specialty
Radiofrequency ablation
medicine.medical_treatment
peri-tumoral injection
chemotherapy
030218 nuclear medicine & medical imaging
law.invention
03 medical and health sciences
0302 clinical medicine
In vivo
law
medicine
liver malignancies
Doxorubicin
RC254-282
Original Research
radiofrequency hyperthermia
Chemotherapy
business.industry
Therapeutic effect
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
image-guided interventional oncology
In vitro
Oncology
Apoptosis
030220 oncology & carcinogenesis
business
medicine.drug
Subjects
Details
- ISSN :
- 2234943X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Oncology
- Accession number :
- edsair.doi.dedup.....ee7e9f676d7c579bf1f87382d4b45070
- Full Text :
- https://doi.org/10.3389/fonc.2021.593996