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Elucidating the Relationship Between Maternal Diabetes and Neonatal Abstinence Syndrome: A 2017-2018 Project WATCH Study in Rural Appalachia
- Source :
- Adv Neonatal Care
- Publication Year :
- 2023
-
Abstract
- BACKGROUND: Previous research indicated that diabetes during pregnancy results in a more permeable placenta. Based on this data, we hypothesized that women with maternal diabetes were more likely to have infants who developed neonatal abstinence syndrome (NAS). PURPOSE: The purpose of the study was to examine the association between maternal diabetes and NAS in a cohort of women reporting substance use during pregnancy. METHODS: This study used data from a population-based cohort of all newborns born in 2017 and 2018 (N = 36,974) in the state of West Virginia and restricted the analysis to those infants with intrauterine substance exposure (14%, n = 5188). Multiple logistic regression was performed to analyze the adjusted relationship between maternal diabetes and NAS while controlling for maternal and infant covariates. RESULTS: Just over 28% of women with diabetes had an infant who developed NAS, whereas 34.8% of women without diabetes had an infant who developed NAS. The adjusted odds ratio of infants developing NAS born to women with diabetes was 0.70 (95% confidence interval: 0.51, 0.94) compared with those born to mothers without diabetes after controlling for covariates. Contrary to our hypothesis, the study suggests that maternal diabetes during pregnancy is associated with a decreased risk of an infant developing NAS. IMPLICATIONS FOR PRACTICE: Future research generating from this hypothesis may lead to potential implications for practice for infants born to mothers with substance use during pregnancy and diabetes. IMPLICATIONS FOR RESEARCH: More research should be conducted to investigate the relationship between glucose metabolism and NAS.
- Subjects :
- medicine.medical_specialty
Substance-Related Disorders
Population
Mothers
Logistic regression
Article
Cohort Studies
Pregnancy
Diabetes mellitus
Diabetes Mellitus
Medicine
Humans
education
Retrospective Studies
education.field_of_study
Appalachian Region
business.industry
Obstetrics
Infant, Newborn
Infant
General Medicine
Odds ratio
medicine.disease
Opioid-Related Disorders
Confidence interval
Pregnancy Complications
Child, Preschool
Pediatrics, Perinatology and Child Health
Cohort
Female
business
Appalachia
Neonatal Abstinence Syndrome
Subjects
Details
- ISSN :
- 15360911
- Volume :
- 22
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Advances in neonatal care : official journal of the National Association of Neonatal Nurses
- Accession number :
- edsair.doi.dedup.....ee7bae8cc6931f48a40ae88253e04fd8