Back to Search
Start Over
Initial Presentation Sites as Predictors of Herpes Zoster Complications: A Nationwide Cohort Study
- Source :
- PLoS ONE, Vol 11, Iss 10, p e0164019 (2016), PLoS ONE
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- Herpes zoster (HZ) is associated with complications such as postherpetic neuralgia (PHN) and HZ ophthalmicus (HZO). However, few studies have focused on identifying patients having a high risk of PHN and HZO according to the initial presentation sites. The current study investigated these factors in a nationwide population-based cohort derived from Taiwan’s Longitudinal Health Insurance Database. The results indicate that the initial presentation sites can predict the complication site of HZ. In this study, elderly patients were found to be more susceptible to HZ and were the first to present with neurological signs (HZN). Furthermore, compared with patients with HZO and other signs (HZT), those with HZN had a higher comorbidity risk. Patients with HZN showed a significantly higher visceral complication risk than did those with HZO (adjusted hazard ratio [HR] = 1.47, 95% confidence interval [CI] = 1.27–1.71). In addition, patients with HZT showed lower risks of ocular and neurological complications than did those with HZN after stratification by age and sex (adjusted HR = 0.46, 95% CI = 0.31–0.68 and HR = 0.73, 95% CI = 0.59–0.91, respectively).
- Subjects :
- Male
Viral Diseases
Chronic Hepatitis
lcsh:Medicine
Blood Pressure
Pathology and Laboratory Medicine
Vascular Medicine
Chronic Liver Disease
Cohort Studies
030207 dermatology & venereal diseases
0302 clinical medicine
Atrial Fibrillation
Medicine and Health Sciences
030212 general & internal medicine
lcsh:Science
education.field_of_study
Multidisciplinary
Liver Diseases
Hazard ratio
Middle Aged
Prognosis
Stroke
Infectious Diseases
Hyperlipidemia
Neurology
Cohort
Hypertension
Female
Arrhythmia
Shingles
Cohort study
Research Article
Risk
medicine.medical_specialty
Cerebrovascular Diseases
Population
Taiwan
Cardiology
Gastroenterology and Hepatology
Herpes Zoster
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Internal medicine
medicine
Humans
education
Retrospective Studies
Heart Failure
Postherpetic neuralgia
business.industry
lcsh:R
Retrospective cohort study
medicine.disease
Comorbidity
Surgery
Age Groups
People and Places
Population Groupings
lcsh:Q
business
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....ee79168dc711027dae2b88b6e281bfc1