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Oxytocin Signal and Social Behaviour: Comparison among Adult and Infant Oxytocin, Oxytocin Receptor and CD38 Gene Knockout Mice
- Source :
- Journal of Neuroendocrinology. 22:373-379
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- 金沢大学医薬保健研究域医学系<br />Oxytocin in the hypothalamus is the biological basis of social recognition, trust, love and bonding. Previously, we showed that CD38, a proliferation marker in leukaemia cells, plays an important role in the hypothalamus in the process of oxytocin release in adult mice. Disruption of Cd38 (Cd38 (-/-)) elicited impairment of maternal behaviour and male social recognition in adult mice, similar to the behaviour observed in Oxt and oxytocin receptor (Oxtr) gene knockout (Oxt (-/-) and Oxtr (-/-), respectively) mice. Locomotor activity induced by separation from the dam was higher and the number of ultrasonic vocalisation calls was lower in Cd38 (-/-) than Cd38( +/+) pups. However, these behavioural changes were much milder than those observed in Oxt (-/-) and Oxtr (-/-) mice, indicating less impairment of social behaviour in Cd38 (-/-) pups. These phenotypes appeared to be caused by the high plasma oxytocin levels during development from the neonatal period to 3-week-old juvenile mice. ADP-ribosyl cyclase activity was markedly lower in the knockout mice from birth, suggesting that weaning for mice is a critical time window of plasma oxytocin differentiation. Breastfeeding was an important exogenous source of plasma oxytocin regulation before weaning as a result of the presence of oxytocin in milk and the dam's mammary glands. The dissimilarity between Cd38 (-/-) infant behaviour and those of Oxt (-/-) or Oxtr (-/-) mice can be explained partly by this exogenous source of oxytocin. These results suggest that secretion of oxytocin into the brain in a CD38-dependent manner may play an important role in the development of social behaviour.
- Subjects :
- Central Nervous System
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Oxytocin
Mice
Cellular and Molecular Neuroscience
Endocrinology
Internal medicine
medicine
Animals
Weaning
ADP-ribosyl Cyclase
Social Behavior
Receptor
Gene knockout
Endocrine and Autonomic Systems
ADP-ribosyl Cyclase 1
Oxytocin receptor
Receptors, Oxytocin
Hypothalamus
Knockout mouse
Female
Psychology
Cyclase activity
Locomotion
hormones, hormone substitutes, and hormone antagonists
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 13652826 and 09538194
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroendocrinology
- Accession number :
- edsair.doi.dedup.....ee78961220d57c29124b247410ddc70e