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Successful Mandibular Mucormycosis Treatment in the Severely Neutropenic Patient
- Source :
- Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 77(6)
- Publication Year :
- 2019
-
Abstract
- Purpose Mucormycosis is a rare opportunistic and aggressive deep fungal infection that predominantly affects immunocompromised patients, and its mortality rate has been reported as up to 80%. Typing of the infection is based mainly on clinical and anatomic presentations, with the most common being the rhinocerebral type. Materials and Methods This report presents 3 patients with cancer who had successful treatment of mandibular mucormycosis. Chemotherapy was administered 13 to 30 days before diagnosis of the infection, resulting in neutropenia in all patients. Each case is thoroughly presented from initial admission through its diagnosis and treatment sequence. Results Early surgical ablative treatment and antifungal treatment resulted in the resolution of infection in all patients. Absolute neutrophil count increased 7 to 8 days after surgical debridement. Conclusions Bringing patients to the post-neutropenic state tremendously increases their odds for survival.
- Subjects :
- medicine.medical_specialty
Antifungal Agents
Neutropenia
medicine.medical_treatment
03 medical and health sciences
Immunocompromised Host
0302 clinical medicine
medicine
Humans
Mucormycosis
Chemotherapy
Debridement
business.industry
Mortality rate
Cancer
030206 dentistry
medicine.disease
Surgery
Neutropenic patient
Otorhinolaryngology
030220 oncology & carcinogenesis
Absolute neutrophil count
Oral Surgery
business
Subjects
Details
- ISSN :
- 15315053
- Volume :
- 77
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
- Accession number :
- edsair.doi.dedup.....ee77797cabd5f77f52c06eb9e9894458