Back to Search
Start Over
Untangling the relationship between fat distribution, nutritional status and Parkinson’s disease severity
- Source :
- Aging Clinical and Experimental Research
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background Parkinson’s disease (PD) is responsible for significant changes in body composition. Aims We aimed to test the association between PD severity and fat distribution patterns, and to investigate the potential modifier effect of nutritional status in this association. Methods We enrolled 195 PD subjects consecutively admitted to a university geriatric day hospital. All participants underwent comprehensive clinical evaluation, including assessment of total and regional body composition (dual-energy X-ray absorptiometry, DXA), body mass index, nutritional status (Mini-Nutritional Assessment, MNA), motor disease severity (UPDRS III), comorbidities, and pharmacotherapy. Results The fully adjusted linear regression model showed a negative association between UPDRS III and total body fat in kg and percentage (respectively, B − 0.79; 95% CI − 1.54 to − 0.05 and B − 0.55; 95% CI − 1.04 to − 0.05), percentage android fat (B − 1.07; 95% CI − 1.75 to − 0.39), trunk–leg fat ratio (B − 0.02; 95% CI − 0.04 to − 0.01), trunk–limb fat ratio (B − 0.01; 95% CI − 0.06 to − 0.01) and android–gynoid fat ratio (B − 0.01; 95% CI − 0.03 to − 0.01). After stratification by MNA score, all the parameters of android-like fat distribution resulted negatively associated (p
- Subjects :
- Adult
Male
Aging
medicine.medical_specialty
Parkinson's disease
Nutritional Status
Disease
Body composition
Severity of Illness Index
03 medical and health sciences
Absorptiometry, Photon
0302 clinical medicine
Pharmacotherapy
Internal medicine
medicine
Humans
030212 general & internal medicine
Geriatric Assessment
Adiposity
Aged
DXA
Geriatrics
business.industry
Parkinson Disease
Nutritional status
Middle Aged
medicine.disease
Malnutrition
Cross-Sectional Studies
Fat
Parkinson’s disease
Linear Models
Original Article
Female
Android fat distribution
Geriatrics and Gerontology
business
Body mass index
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 17208319
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Aging Clinical and Experimental Research
- Accession number :
- edsair.doi.dedup.....ee6b6eaf5cbe35ceb09829e9cb89c1ed