Etravirine protects the activity of darunavir in the DUET trials

Methods In this analysis, patients with a virologic rebound were defined as those who showed a virologic response at earlier time-points but rebounded to >50 copies/ml in the DUET week 48 dataset. Phenotyping and genotyping at baseline and end-point were performed with the AntivirogramTM and Virco® TYPE HIV-1 assays, respectively, if viral load (VL) was >1000 copies/ml. Emerging mutations were those present at end-point (i.e. the last available resistance test on treatment) but not at baseline. Patients who discontinued the trial for non-virologic reasons were excluded.