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Hypercalcaemia in rheumatoid arthritis: investigation of its causes and implications
- Publication Year :
- 1979
-
Abstract
- When correction was made for hypoalbuminaemia, 23 of 50 ambulant patients with definite or classical rheumatoid arthritis were found to have hypercalcaemia. When these 23 patients were studied 6 months later, 7 had hypercalcaemia as defined by the correction factor for a low serum albumin level, and 6 of these patients had raised serum ionised calcium concentrations. Biochemical studies in the 23 patients indicated evidence of hyperparathyroidism, namely, hypophosphataemia, increased serum alkaline phosphatase, hyperchloraemia, and reduced tubular reabsorption of calcium. However, serum immunoreactive parathyroid hormone concentrations were normal. Only one patient had an abnormally low serum 25-hydroxy-vitamin D result: this patient had a high level of urinary D-glucaric acid and was receiving phenobarbitone for treatment of epilepsy. The biochemical features suggestive of parathyroid overactivity were particularly found in patients with raised serum calcium levels. The cause of hypercalcaemia in rheumatoid arthritis remains to be explained.
- Subjects :
- Adult
medicine.medical_specialty
Hypercalcaemia
Urinary system
Immunology
Arthritis
chemistry.chemical_element
Parathyroid hormone
Calcium
General Biochemistry, Genetics and Molecular Biology
Arthritis, Rheumatoid
Rheumatology
Reference Values
Internal medicine
medicine
Immunology and Allergy
Humans
Serum Albumin
Aged
Hyperparathyroidism
business.industry
Middle Aged
medicine.disease
Endocrinology
chemistry
Renal physiology
Rheumatoid arthritis
Hypercalcemia
Female
business
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....ee65f7e8a185801f5ef9efc7e416ae7e