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Rational design and synthesis of selective BACE-1 inhibitors
- Source :
- Bioorganic & Medicinal Chemistry Letters. 14:601-604
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- An effective approach for enhancing the selectivity of beta-site amyloid precursor protein cleaving enzyme (BACE 1) inhibitors is developed based on the unique features of the S1' pocket of the enzyme. A series of low molecular weight (
- Subjects :
- Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Cathepsin D
Biochemistry
Chemical synthesis
Substrate Specificity
Alzheimer Disease
Endopeptidases
Renin
Drug Discovery
Amyloid precursor protein
Aspartic Acid Endopeptidases
Humans
Enzyme Inhibitors
Molecular Biology
chemistry.chemical_classification
Molecular Structure
biology
Chemistry
Organic Chemistry
Rational design
Molecular Weight
Enzyme
Enzyme inhibitor
Drug Design
biology.protein
Molecular Medicine
Amyloid Precursor Protein Secretases
Propionates
Selectivity
Amyloid precursor protein secretase
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....ee644b37ff3d7b4857c750f265677011
- Full Text :
- https://doi.org/10.1016/j.bmcl.2003.11.061