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Fenfluramine challenge test as a marker of serotonin activity in patients with Alzheimer's dementia and agitation
- Source :
- Biological psychiatry. 44(9)
- Publication Year :
- 1998
-
Abstract
- Background: Changes in serotonin (5-HT) have been described in both Alzheimer’s disease (AD) and aggressive/agitated behaviors. This paper explores a possible association between 5-HT deficits and agitation in AD, using prolactin response to d,1-fenfluramine administration as a probe for 5-HT activity. Methods: Five AD patients with agitation and 5 without agitation received a 60-mg oral dose of d,1-fenfluramine. Prolactin levels were obtained at baseline, and 2 and 3 hours following administration. Results: Change in prolactin levels from baseline to 3 hours was significantly larger among the agitated than the nonagitated Alzheimer’s patients. Further, there was a positive and significant correlation between change in prolactin levels from baseline and level of agitation. Conclusions: These findings suggest an association between 5-HT responsiveness and agitation in AD.
- Subjects :
- Male
medicine.medical_specialty
Serotonin
Fenfluramine
Behavioral Symptoms
Central nervous system disease
chemistry.chemical_compound
Serotonin Agents
Alzheimer Disease
Internal medicine
medicine
Dementia
Humans
Neurotransmitter
Biological Psychiatry
Psychomotor Agitation
Aged
Aged, 80 and over
medicine.disease
Prolactin
Endocrinology
chemistry
Case-Control Studies
Female
Alzheimer's disease
Psychology
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 00063223
- Volume :
- 44
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Biological psychiatry
- Accession number :
- edsair.doi.dedup.....ee63a59c96c34d6e0361383a4f3674e5