Back to Search Start Over

Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus

Authors :
on behalf of the European MID-Frail Consortium
Rodríguez-Mañas, Leocadio
Laosa, Olga
Vellas, Bruno
Paolisso, Giuseppe
Topinkova, Eva
Oliva-Moreno, Juan
Bourdel-Marchasson, Isabelle
Izquierdo, Mikel
Hood, Kerry
Zeyfang, Andrej
Gambassi, Giovanni
Petrovic, Mirko
Hardman, Tim C.
Kelson, Mark J.
Bautmans, Ivan
Abellan, Gabor
Barbieri, Michelangela
Peña-Longobardo, Luz M.
Regueme, Sophie C.
Calvani, Riccardo
De Buyser, Stefanie
Sinclair, Alan J.
Department of Social Gerontology
Research in Geriatrics and Gerontology
Gerontology
Rehabilitation Research
Physical Medicine and Rehabilitation
Frailty in Ageing
Universidad Pública de Navarra. Departamento de Ciencias de la Salud
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila
Rodriguez‐mañas, Leocadio
Laosa, Olga
Vellas, Bruno
Paolisso, Giuseppe
Topinkova, Eva
Oliva‐moreno, Juan
Bourdel‐marchasson, Isabelle
Izquierdo, Mikel
Hood, Kerry
Zeyfang, Andrej
Gambassi, Giovanni
Petrovic, Mirko
Hardman, Tim C.
Kelson, Mark J.
Bautmans, Ivan
Abellan, Gabor
Barbieri, Michelangela
Peña‐longobardo, Luz M.
Regueme, Sophie C.
Calvani, Riccardo
De Buyser, Stefanie
Sinclair, Alan J.
behalf of the European MID‐Frail Consortium, On
Source :
Journal of Cachexia, Sarcopenia and Muscle, JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, Academica-e: Repositorio Institucional de la Universidad Pública de Navarra, Universidad Pública de Navarra, Academica-e. Repositorio Institucional de la Universidad Pública de Navarra, instname, Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 4, Pp 721-733 (2019)
Publication Year :
2019

Abstract

Background Type 2 diabetes, a highly prevalent chronic disease, is associated with increasing frailty and functional decline in older people. We aimed to evaluate the effectiveness of a multimodal intervention on functional performance in frail and pre‐frail participants aged ≥70 years with type 2 diabetes mellitus. Methods The MID‐Frail study was a cluster‐randomized multicenter clinical trial conducted in 74 trial sites across seven European countries. The trial recruited 964 participants who were aged >70 years [mean age in intervention group, 78.4 (SD 5.6) years, 49.2% male and 77.6 (SD 5.29) years, 52.4% male in usual care group], with type diabetes mellitus and determined to be frail or pre‐frail using Fried's frailty phenotype. Participants were allocated by trial site to follow either usual care (UCG) or intervention procedures (IG). Intervention group participants received a multimodal intervention composed of (i) an individualized and progressive resistance exercise programme for 16 weeks; (ii) a structured diabetes and nutritional educational programme over seven sessions; and (iii) Investigator‐linked training to ensure optimal diabetes care. Short Physical Performance Battery (SPPB) scores were used to assess change in functional performance at 12 months between the groups. An analysis of the cost‐effectiveness of the intervention was undertaken using the incremental cost‐effectiveness ratio (ICER). Secondary outcomes included mortality, hospitalization, institutionalization, quality of life, burden on caregivers, the frequency and severity of hypoglycaemia episodes, and the cost‐effectiveness of the intervention. Results After 12 months, IG participants had mean SPPB scores 0.85 points higher than those in the UCG (95% CI, 0.44 to 1.26, P

Details

ISSN :
21906009 and 21905991
Volume :
10
Issue :
4
Database :
OpenAIRE
Journal :
Journal of cachexia, sarcopenia and muscle
Accession number :
edsair.doi.dedup.....ee6380b4d0939bea078133169b2f5074