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Comparison of Frequency and Severity of Sleep-Related Breathing Disorders in Children with Simple Obesity and Paediatric Patients with Prader–Willi Syndrome
- Source :
- Journal of Personalized Medicine, Vol 11, Iss 141, p 141 (2021), Journal of Personalized Medicine, Volume 11, Issue 2
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Sleep-related breathing disorders (SRBDs) can be present in children with simple obesity and with Prader–Willi syndrome (PWS) and influence an individual diagnostic and treatment approach. We compared frequency and severity of SRBDs in children with simple obesity and with PWS, both without and on recombinant human growth hormone (rhGH) treatment, and correlation of SRBDs with insulin resistance tests. A screening polysomnography-polygraphy (PSG), the oral glucose tolerance test (OGTT) and homeostasis model assessment of insulin resistance (HOMA-IR) were analysed in three groups of patients—with simple obesity (group 1, n = 30, mean age 14.2 years), patients with PWS without the rhGH therapy (group 2, n = 8, mean age 13.0 years) and during the rhGH treatment (group 3, n = 17, mean age 8.9 years). The oxygen desaturation index (ODI) was significantly higher in groups 2 and 3, compared to group 1 (p = 0.00), and hypopnea index (HI) was higher in group 1 (p = 0.03). Apnea–hypopnea index (AHI) and apnea index (AI) results positively correlated with the insulin resistance parameters in groups 1 and 3. The PSG values worsened along with the increasing insulin resistance in children with simple obesity and patients with PWS treated with rhGH that may lead to a change in the patients’ care.
- Subjects :
- Pediatrics
medicine.medical_specialty
Central sleep apnea
Prader–Willi syndrome
sleep-related breathing disorders
Medicine (miscellaneous)
lcsh:Medicine
Article
central sleep apnea
03 medical and health sciences
0302 clinical medicine
Insulin resistance
030225 pediatrics
medicine
obstructive sleep apnea
Paediatric patients
business.industry
lcsh:R
Apnea
nutritional and metabolic diseases
medicine.disease
Breathing disorders
nervous system diseases
Obstructive sleep apnea
Simple obesity
medicine.symptom
business
Hypopnea
030217 neurology & neurosurgery
simple obesity
Subjects
Details
- Language :
- English
- ISSN :
- 20754426
- Volume :
- 11
- Issue :
- 141
- Database :
- OpenAIRE
- Journal :
- Journal of Personalized Medicine
- Accession number :
- edsair.doi.dedup.....ee5f17a24d2defcab7fcbf18e341bb4f