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Blood groups of Neandertals and Denisova decrypted
- Source :
- Human Evolution-From Fossils to Ancient and Modern Genomes 2021, Human Evolution-From Fossils to Ancient and Modern Genomes 2021, Nov 2021, virtual conference, United Kingdom, PLoS ONE, PLoS ONE, Public Library of Science, 2021, 16 (7), pp.e0254175. ⟨10.1371/journal.pone.0254175⟩, PLoS ONE, Vol 16, Iss 7, p e0254175 (2021), PLoS ONE, 2021, 16 (7), pp.e0254175. ⟨10.1371/journal.pone.0254175⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- International audience; Red cell blood group systems are crucial for safe transfusion, transplantation, and pregnancy monitoring. In addition, blood groups have long been investigated to decipher the origin of human populations, migration, adaptation, and admixture. However, since the extensive use of DNA polymorphisms in Anthropology, blood groups have been relegated to their primary application, blood transfusion. The finer genomic mapping of some Neanderthal and Denisova individuals about modern humans has provided significant evidence on the evolutionary history of both archaic and modern humans. However, despite their medical and anthropological interest, little is known about blood groups in archaic populations. To better understand the origin, expansion and encounter with Homo sapiens, we reappraised the available high-quality sequences of three Neanderthals (Vindija 33.19, Chagyrskaya 8, Altai Neandertal) and one Denisovan (Denisova 3) for 11 genes of the 7 blood group systems that are routinely screened in transfusion: ABO including H/ Se, Rh (Rhesus), Kell, Duffy, Kidd, MNS, and Diego. We show that Neanderthals and Denisova were polymorphic for ABO and shared blood group alleles recurrent in modern Sub-Saharan populations. Furthermore, we found ABO-related alleles currently preventing viral gut infection and all Neanderthal shared RHD and RHCE alleles nowadays associated with a high risk of hemolytic disease of the fetus and newborn. Such a common blood group pattern across time and space is coherent with a Neanderthal population of low genetic diversity exposed to possible pregnancies with complications. Lastly, we connect the Neanderthal RHD allele to two present-day Aboriginal Australians and Papuan, suggesting that a segment of the archaic genome was introgressed in this gene in non-Eurasian populations before their expansion towards Oceania. While contributing to both the origin and late evolutionary history of Neanderthal and Denisova, our results further illustrate that blood group systems remain effective anthropological markers.
- Subjects :
- 0301 basic medicine
Neanderthal
Hominids
Heredity
Physiology
[SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology
Social Sciences
Homozygosity
0302 clinical medicine
INDEL Mutation
Medicine and Health Sciences
Neanderthals
education.field_of_study
Multidisciplinary
biology
Fossils
Paleogenetics
Hominidae
Body Fluids
[SHS.ANTHRO-BIO] Humanities and Social Sciences/Biological anthropology
Genetic Mapping
Blood
Phenotype
Blood Group Antigens
Medicine
Physical Anthropology
Anatomy
Research Article
Genotype
Science
Population
Variant Genotypes
03 medical and health sciences
Archaic Humans
ABO blood group system
biology.animal
Paleoanthropology
Genetic variation
Genetics
Hominins
Animals
Allele
education
Denisovan
Alleles
Evolutionary Biology
Polymorphism, Genetic
Population Biology
Haplotype
Biology and Life Sciences
Paleontology
Genetic Variation
biology.organism_classification
030104 developmental biology
Haplotypes
Evolutionary biology
Genetic Loci
Anthropology
Earth Sciences
Blood Groups
030217 neurology & neurosurgery
Population Genetics
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- Human Evolution-From Fossils to Ancient and Modern Genomes 2021, Human Evolution-From Fossils to Ancient and Modern Genomes 2021, Nov 2021, virtual conference, United Kingdom, PLoS ONE, PLoS ONE, Public Library of Science, 2021, 16 (7), pp.e0254175. ⟨10.1371/journal.pone.0254175⟩, PLoS ONE, Vol 16, Iss 7, p e0254175 (2021), PLoS ONE, 2021, 16 (7), pp.e0254175. ⟨10.1371/journal.pone.0254175⟩
- Accession number :
- edsair.doi.dedup.....ee54fc8f2635ca009b8d8f22d503a545