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Macular edema secondary to retinal vein occlusion in a real-life setting: a multicenter, nationwide, 3-year follow-up study
- Source :
- Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 259(2)
- Publication Year :
- 2020
-
Abstract
- Purpose: To evaluate the presence of macular edema secondary to retinal vein occlusion (RVO)-both central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO)-3 years after diagnosis in patients who underwent intravitreal therapy and to identify potential prognostic factors and biomarkers of persistent macular edema. Methods: National multicenter, observational, exploratory, retrospective cohort study of 104 consecutive patients with macular edema secondary to RVO diagnosed from January 2014 to December 2015 with minimum 3-year follow-up time. Data analyzed included best-corrected visual acuity (BCVA), clinical and demographic data, and spectral domain optical coherence tomography parameters. Results: At final observation, median baseline central retinal thickness significantly improved from baseline 538 to 290 μm (p < 0.001) and complete macular edema resolution was achieved in 51.0% of patients (56.3% and 42.5% in BRVO and CRVO patients, respectively). BCVA also improved (p < 0.01). Logistic regression analysis revealed a relationship between recurrence of macular edema and disorganization of retinal inner layers (DRIL) at baseline (odds ratio = 2.88; p = 0.013). Conclusion: Good long-term anatomical and functional outcomes are achieved with intravitreal treatments in RVO patients. Anatomical success and visual gains seen in the first year were maintained throughout the entire follow-up, though DRIL is a major risk factor for recurrence. info:eu-repo/semantics/publishedVersion
- Subjects :
- medicine.medical_specialty
Retinal Vein
Visual acuity
genetic structures
Disorganization of retinal inner layers
Visual Acuity
Angiogenesis Inhibitors
Macular Edema
Retinal vein occlusion
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Vision loss
Central retinal vein occlusion
Ophthalmology
Occlusion
Retinal Vein Occlusion
medicine
Humans
Macular edema
Retrospective Studies
Intravitreal injections
business.industry
Anti-VEGF
HSAC OFT
Retinal
Retrospective cohort study
medicine.disease
eye diseases
Sensory Systems
Chronic macular edema
Treatment Outcome
chemistry
Intravitreal Injections
030221 ophthalmology & optometry
Branch retinal vein occlusion
medicine.symptom
business
030217 neurology & neurosurgery
Tomography, Optical Coherence
Follow-Up Studies
Subjects
Details
- ISSN :
- 1435702X
- Volume :
- 259
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
- Accession number :
- edsair.doi.dedup.....ee52e171d42e60f29fd88329b2259054