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Association between Intracranial Atherosclerotic Calcium Burden and Angiographic Luminal Stenosis Measurements
- Publication Year :
- 2017
-
Abstract
- BACKGROUND AND PURPOSE: Calcification of the intracranial vasculature is an independent risk factor for stroke. The relationship between luminal stenosis and calcium burden in the intracranial circulation is incompletely understood. We evaluated the relationship between atherosclerotic calcification and luminal stenosis in the intracranial ICAs. MATERIALS AND METHODS: Using a prospective stroke registry, we identified patients who had both NCCT and CTA or MRA examinations as part of a diagnostic evaluation for ischemic stroke. We used NCCTs to qualitatively (modified Woodcock Visual Score) and quantitatively (Agatston-Janowitz Calcium Score) measure ICA calcium burden and used angiography to measure arterial stenosis. We calculated correlation coefficients between the degree of narrowing and calcium burden measures. RESULTS: In 470 unique carotid arteries (235 patients), 372 (79.1%) had atherosclerotic calcification detectable on CT compared with 160 (34%) with measurable arterial stenosis on CTA or MRA (P CONCLUSIONS: There is a weak correlation between intracranial atherosclerotic calcium scores and luminal narrowing, which may be explained by the greater sensitivity of CT than angiography in detecting the presence of measurable atherosclerotic disease. Future studies are warranted to evaluate the relationship between stenosis and calcium burden in predicting stroke risk.
- Subjects :
- Male
medicine.medical_specialty
030204 cardiovascular system & hematology
Risk Assessment
Magnetic resonance angiography
Article
Brain Ischemia
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Carotid Stenosis
cardiovascular diseases
Prospective Studies
Risk factor
Stroke
Aged
Aged, 80 and over
medicine.diagnostic_test
Arterial stenosis
business.industry
Calcinosis
Reproducibility of Results
Middle Aged
medicine.disease
Intracranial Arteriosclerosis
Cerebral Angiography
Stenosis
Angiography
Cardiology
Calcium
Female
Neurology (clinical)
Radiology
business
Tomography, X-Ray Computed
030217 neurology & neurosurgery
Carotid Artery, Internal
Magnetic Resonance Angiography
Calcification
Cerebral angiography
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....ee4e379496ad22809679542db1dfb0b6